Shribman A J, Hanning C D
Eur J Anaesthesiol. 1986 Mar;3(2):103-10.
A new spinal analgesic formulation, 'heavy bupivacaine', was compared clinically with a commonly used agent. Sixty patients, who required spinal analgesia for transurethral prostatectomy, received either 1.5 ml of hyperbaric 0.5% cinchocaine (Nupercaine, Percaine, Dibucaine) in 6% dextrose or 2.5 ml of hyperbaric 0.5% bupivacaine (Marcain) in 8% dextrose. The onset, rate of rise, plateau height of the sensory block, reduction in blood pressure and peak expiratory flow rate, and the operative and post-operative blood loss did not differ significantly. Motor blockade was significantly less with bupivacaine. It is concluded that hyperbaric bupivacaine is an acceptable alternative to hyperbaric cinchocaine for spinal analgesia for transurethral prostatectomy.
一种新的脊髓镇痛制剂“重比重布比卡因”与一种常用制剂进行了临床比较。60例因经尿道前列腺切除术需要脊髓镇痛的患者,分别接受了1.5毫升含6%葡萄糖的高比重0.5%辛可卡因(纽白卡因、奴夫卡因、地布卡因)或2.5毫升含8%葡萄糖的高比重0.5%布比卡因(耐乐品)。感觉阻滞的起效时间、上升速率、平台高度、血压降低和呼气峰值流速,以及手术中和术后的失血量均无显著差异。布比卡因引起的运动阻滞明显较轻。结论是,对于经尿道前列腺切除术的脊髓镇痛,高比重布比卡因是高比重辛可卡因的可接受替代药物。