Das Umesh, Appaji L, Kumari B S Aruna, Lakshmaiah K C, Padma M, Kavitha S, Sathyanarayanan Vishwanath
Department of Medical Oncology, Kidwai Memorial Institute of Oncology , Banglore, Karnataka , India.
Pediatr Hematol Oncol. 2014 Sep;31(6):489-97. doi: 10.3109/08880018.2013.852644. Epub 2013 Dec 5.
The diagnosis and management of cancer in infantile age group is a significant challenge to pediatric oncologists. Malignancies occurring in infants often have different clinical and biological behavior in comparison to older children. This study was performed with an aim to find out the profile of infantile cancers at a tertiary care cancer center in South India.
The present study was a retrospective analysis of infants presenting with malignancy between 2003 and 2012 to our center in South India.
A total of 4588 pediatric patients were registered in the Department of Pediatric Oncology at our institute between 2003 and 2012. Among those, 266 (5.79%) of the patients were infants (0-1 years). There were 65.75% males and 34.25% females. Solid tumors were the most common malignancy in this age group (72.56%). Leukemias were observed in 67 (25.19%) infants. ALL was the most common hematological malignancy (17.29%) followed by AML (5.64%). Common solid tumors in descending orders were neuroblastoma, soft tissue sarcoma, renal tumors, germ cell tumors, retinoblastoma and hepatoblastoma. Thirteen (4.89%) neonates were seen in our study. The most common malignancy in neonates was neuroblastoma.
The distribution of malignancy in infants is quite different from that which is found in older children. Although neuroblastoma is the most common infantile tumor in western countries, in our study leukemia is the most common infantile malignancy. Embryonal tumors such as neuroblastoma, Wilms tumor, retinoblastoma, and hepatoblastoma were more prevalent in infants. Solid tumors were the most common malignancy in infants which is followed by leukemia.
婴儿期癌症的诊断与治疗对儿科肿瘤学家而言是一项重大挑战。与大龄儿童相比，婴儿期发生的恶性肿瘤往往具有不同的临床和生物学行为。本研究旨在了解印度南部一家三级护理癌症中心的婴儿癌症概况。
本研究是对2003年至2012年间在印度南部我们中心就诊的患有恶性肿瘤的婴儿进行的回顾性分析。
2003年至2012年间，我们研究所的儿科肿瘤学部门共登记了4588名儿科患者。其中，266名（5.79%）患者为婴儿（0至1岁）。男性占65.75%，女性占34.25%。实体瘤是该年龄组最常见的恶性肿瘤（72.56%）。67名（25.19%）婴儿患有白血病。急性淋巴细胞白血病是最常见的血液系统恶性肿瘤（17.29%），其次是急性髓系白血病（5.64%）。按降序排列，常见的实体瘤有神经母细胞瘤、软组织肉瘤、肾肿瘤、生殖细胞瘤、视网膜母细胞瘤和肝母细胞瘤。我们的研究中发现了13名（4.89%）新生儿。新生儿中最常见的恶性肿瘤是神经母细胞瘤。
婴儿期恶性肿瘤的分布与大龄儿童有很大不同。虽然在西方国家神经母细胞瘤是最常见的婴儿肿瘤，但在我们的研究中白血病是最常见的婴儿恶性肿瘤。神经母细胞瘤、肾母细胞瘤、视网膜母细胞瘤和肝母细胞瘤等胚胎性肿瘤在婴儿中更为普遍。实体瘤是婴儿中最常见的恶性肿瘤，其次是白血病。
