Cytology Division, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.
Histopathology Division, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.
Diagn Cytopathol. 2021 Jun;49(6):743-752. doi: 10.1002/dc.24735. Epub 2021 Mar 11.
Neuroblastoma (NB), Wilms tumor (WT), hepatoblastoma (HBL), germ cell tumors (GCT), rhabdomyosarcoma (RMS), and so forth are the commonly identified solid tumors in infants. Invasive diagnostic techniques are more challenging in infants than older children. fine needle aspiration cytology (FNAC) is a safe, minimally invasive and outpatient procedure which is time and cost-effective for solid tumor diagnosis. This study aims to evaluate the role of FNAC in the diagnosis of various infantile solid tumors.
In this retrospective study, 61 cases of FNA of infant solid tumors were retrieved from the cytology archives over a period of 5 years from January 2013 to December 2017. Cytomorphology was studied and immunohistochemistry on cell block was performed wherever feasible. Histopathological correlation was done in 19 cases.
Of the 61 cases studied, 60 cases were included in the study of which 35 were male and 25 were female. Infantile solid tumors constituted 7.3% of all pediatric solid tumors reported in cytopathology division of our Institute. The most common final diagnosis was NB (15, 25%) followed by HBL (13, 21.6%), WT (10, 16.6%), RMS (nine, 15%) and GCT (nine, 15%). The commonest site was abdominal-pelvic (42, 70%). A definitive independent diagnosis could be made on FNA in 48 cases (80%). Follow-up was done for 1.5 to 4 years (mean 26 months). The highest and lowest mortality was noted in NB (64.3%) and WT (12.5%) respectively.
This study concludes that FNAC can be adopted as a diagnostic modality in infant solid tumors.
神经母细胞瘤（NB）、肾母细胞瘤（WT）、肝母细胞瘤（HBL）、生殖细胞肿瘤（GCT）、横纹肌肉瘤（RMS）等是婴儿中常见的实体瘤。与大龄儿童相比，婴儿的侵袭性诊断技术更具挑战性。细针穿刺细胞学（FNAC）是一种安全、微创、门诊的诊断方法，对于实体瘤的诊断具有时间和成本效益。本研究旨在评估 FNAC 在诊断各种婴儿实体瘤中的作用。
在这项回顾性研究中，从 2013 年 1 月至 2017 年 12 月的 5 年内，从细胞学档案中检索到 61 例婴儿实体肿瘤的 FNAC 病例。研究了细胞形态学，并在可行的情况下对细胞块进行了免疫组织化学染色。在 19 例病例中进行了组织病理学相关性研究。
在研究的 61 例病例中，有 60 例被纳入研究，其中男性 35 例，女性 25 例。婴儿实体肿瘤在我院细胞病理学科报告的所有儿科实体肿瘤中占 7.3%。最常见的最终诊断是 NB（15 例，25%），其次是 HBL（13 例，21.6%）、WT（10 例，16.6%）、RMS（9 例，15%）和 GCT（9 例，15%）。最常见的部位是腹部-盆腔（42 例，70%）。在 48 例（80%）病例中，FNAC 可做出明确的独立诊断。随访时间为 1.5 至 4 年（平均 26 个月）。NB（64.3%）和 WT（12.5%）的死亡率最高和最低。
本研究表明，FNAC 可作为婴儿实体肿瘤的一种诊断方法。
