Department of Chemistry, School of Science and Technology, Kwansei Gakuin University , 2-1 Gakuen, Sanda, Hyogo 669-1337, Japan.
Org Lett. 2014 Jan 3;16(1):286-9. doi: 10.1021/ol4032792. Epub 2013 Dec 5.
Two-directional annulation of dibromoisobenzofuran, a formal equivalent to didehydroisobenzofuran, was developed. Importantly, selective bromine-lithium exchange allows the tandem generation of benzynes and dual cycloadditions with two different arynophiles. Also described is the application to the synthesis of a substituted pentacene.
二溴苯并呋喃（二氢异苯并呋喃的等价物）的双向环化反应得到了发展。重要的是，选择性的溴-锂交换允许苯炔的串联生成和与两个不同芳基亲电试剂的双重环加成。还描述了该方法在取代的并五苯合成中的应用。
