Hadders-Algra M, Touwen B C, Huisjes H J
Dev Med Child Neurol. 1986 Oct;28(5):569-78. doi: 10.1111/j.1469-8749.1986.tb03898.x.
Of 1655 newborns examined neurologically at term, 80 were found to be abnormal. 76 were traced at six years of age, together with a control group of 77 neonatally normal children. In the study group five children had died, six were severely handicapped and 21 had minor neurological dysfunction (MND). In the control group two had died and four had MND. Obstetrical and neonatal paediatric effects, as well as complications in the intervening years, appeared to have a cumulative effect on the relationship between the neonatal neurological condition and the neurological findings at six years. There were no large differences in behaviour between the study group and the controls, but the study-group MND children showed a stronger tendency for undesirable behaviour and poor school achievements. Although environmental influences are preponderant for the development of behaviour and school performance, a contribution of both neonatal and later neurological conditions seems likely.
在对1655名足月新生儿进行神经学检查时,发现80名异常。对其中76名在6岁时进行了追踪,同时还有一个由77名新生儿期正常儿童组成的对照组。研究组中有5名儿童死亡,6名严重残疾,21名有轻微神经功能障碍(MND)。对照组中有2名死亡,4名有MND。产科和新生儿期儿科影响以及其间数年的并发症,似乎对新生儿神经状况与6岁时神经学检查结果之间的关系有累积影响。研究组和对照组在行为方面没有太大差异,但研究组中有MND的儿童表现出更强烈的不良行为倾向和学业成绩不佳的情况。虽然环境影响对行为和学业表现的发展起主要作用,但新生儿期和后期的神经状况似乎也有一定作用。