Til H P, Feron V J, Immel H R, Vogel W F
Food Chem Toxicol. 1986 Aug;24(8):825-34. doi: 10.1016/0278-6915(86)90072-4.
A chronic feeding study was carried out in mice with two chemically modified potato starches, hydroxypropyl distarch phosphate (HP-starch) and starch acetate (AC-starch), and with lactose and sodium alginate. Each of the materials was fed to a group of 75 male and 75 female mice for 89 wk. The dietary level of the test products was gradually increased until the diets contained (by weight) 55% HP-starch, 55% AC-starch, 55% lactose or 25% alginate. The control diet contained 55% pregelatinized potato starch. Each of the four test materials caused increased water consumption, distinct caecal and colonic enlargement, a slightly increased incidence of intratubular nephrosis and, with the exception of AC-starch, also slightly lower body weights. An increased incidence of gastric trichobezoars was observed in mice fed either the modified starches or lactose. The occurrence of concrements in the renal pelvis along with slight urinary changes, such as increased amounts of amorphous material in the urine and increased urinary Ca content, in mice fed HP-starch, AC-starch or lactose was regarded as an effect of little, if any, toxicological significance. Alginate fed at 25% (w/w) of the diet was nephrotoxic to mice, as shown by extremely high water consumption, high urine production, urinary incontinence, high pH and low specific gravity of the urine, increased level of blood urea nitrogen, increased kidney weights, distension of the renal calyx and the high incidence of dilated distal tubules. Caecal and colonic enlargement and changes in urinalysis were found to be reversible and had completely or largely disappeared within 2-5 wk of the cessation of the treatment in wk 87. The incidence of intratubular calcinosis or of concrements in the pelvic space was not reduced during the recovery period. The study did not provide any evidence of carcinogenicity of the products tested.
用两种化学改性马铃薯淀粉（羟丙基二淀粉磷酸酯，即HP - 淀粉和醋酸淀粉酯，即AC - 淀粉）、乳糖和海藻酸钠对小鼠进行了一项慢性喂养研究。将每种物质分别喂给一组75只雄性和75只雌性小鼠，持续89周。受试产品的日粮水平逐渐提高，直到日粮中含有（按重量计）55%的HP - 淀粉、55%的AC - 淀粉、55%的乳糖或25%的海藻酸钠。对照日粮含有55%的预糊化马铃薯淀粉。四种受试物质均导致小鼠饮水量增加、盲肠和结肠明显增大、肾小管内肾病的发生率略有增加，并且除AC - 淀粉外，体重也略有降低。在喂食改性淀粉或乳糖的小鼠中观察到胃毛粪石的发生率增加。在喂食HP - 淀粉、AC - 淀粉或乳糖的小鼠中，肾盂内出现结石以及轻微的尿液变化，如尿液中无定形物质增多和尿钙含量增加，被认为即使有也是毒理学意义不大的影响。日粮中25%（w/w）的海藻酸钠对小鼠具有肾毒性，表现为饮水量极高、尿量增加、尿失禁、尿液pH值高和比重低、血尿素氮水平升高、肾脏重量增加、肾盏扩张以及远端肾小管扩张的发生率高。盲肠和结肠增大以及尿液分析变化在第87周停止治疗后的2 - 5周内被发现是可逆的，并且已完全或大部分消失。在恢复期，肾小管内钙化或盆腔空间结石的发生率并未降低。该研究未提供受试产品具有致癌性的任何证据。
