Raja R M
Int J Artif Organs. 1986 Sep;9(5):319-22.
Hemoperfusion through Amberlite XAD-4 resin column has been shown to effectively remove sedative-hypnotics, analgesics and other drugs causing acute intoxication. There is no appreciable clinical toxicity and dramatic shortening of coma time and possible decrease in mortality may be achieved. Thrombocytopenia and clotting may be diminished by pre-perfusion coating with 2.5% albumin. Albumin coating may facilitate the repeated use of hemoperfusion without any complications. More recently, resin hemoperfusion has been used for procainamide, N-acetylprocainamide and theophylline intoxication achieving exceptionally high clearance rates.
通过Amberlite XAD - 4树脂柱进行血液灌流已被证明能有效清除镇静催眠药、镇痛药及其他导致急性中毒的药物。临床无明显毒性，可显著缩短昏迷时间，并可能降低死亡率。通过用2.5%白蛋白进行预灌流包被可减少血小板减少和凝血现象。白蛋白包被可促进血液灌流的重复使用且无任何并发症。最近，树脂血液灌流已用于普鲁卡因胺、N - 乙酰普鲁卡因胺及茶碱中毒，清除率极高。
