Zhang Liangqing, Liu Guohao, Xia Qingping, Deng Li
Department of Anesthesiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Department of Medical Imaging, Affiliated Hospital of Jilin Medical University, Jilin, China.
Front Bioeng Biotechnol. 2024 Oct 1;12:1456694. doi: 10.3389/fbioe.2024.1456694. eCollection 2024.
This comprehensive review examines the latest developments in improving the blood compatibility of hemoperfusion adsorbents. By leveraging advanced coating and modification techniques, including albumin-collodion, cellulose, hydrogel, and heparin coatings, notable enhancements in blood compatibility have been achieved across diverse adsorbent types, such as carbon-based, resin-based, and polysaccharide-based materials. Despite promising laboratory results, the intricate manufacturing processes and elevated costs present significant challenges for broad clinical application. Therefore, future endeavors should focus on cost-benefit analysis, large-scale production strategies, in-depth exploration of blood-material interactions, and innovative technologies to propel the development of safer and more effective blood purification therapies.
这篇综述探讨了改善血液灌流吸附剂血液相容性的最新进展。通过利用先进的涂层和改性技术，包括白蛋白火棉胶、纤维素、水凝胶和肝素涂层，在多种吸附剂类型中，如碳基、树脂基和多糖基材料，血液相容性都有了显著提高。尽管实验室结果很有前景，但复杂的制造工艺和高昂的成本给广泛的临床应用带来了重大挑战。因此，未来的努力应集中在成本效益分析、大规模生产策略、深入探索血液与材料的相互作用以及创新技术上，以推动更安全、更有效的血液净化疗法的发展。
