Eichner R D, Al Salami M, Wood P R, Müllbacher A
Int J Immunopharmacol. 1986;8(7):789-97. doi: 10.1016/0192-0561(86)90016-0.
Gliotoxin, a metabolite of the fungus Aspergillus fumigatus, inhibited phagocytosis of particulate matter by rodent macrophages. In addition, adherence to plastic surfaces by peritoneal and alveolar rodent macrophages, human peripheral blood monocytes, mouse secondary fibroblasts and L929 cells was differentially inhibited by gliotoxin. Electron microscopy which confirmed the inhibition by gliotoxin of phagocytosis of carbon particles by rodent macrophages also revealed gliotoxin-induced morphological alterations. Gliotoxin selectively affected glucose metabolism and macromolecular synthesis of rodent-derived cells and inhibited the basal rate of H2O2 production by human polymorphonuclear neutrophils; bactericidal activity of resident peritoneal macrophages was also abrogated. These gliotoxin-induced changes in cell function and metabolism occurred at concentrations well below generalized toxic levels.
Gliotoxin是烟曲霉真菌的一种代谢产物，它可抑制啮齿动物巨噬细胞对颗粒物的吞噬作用。此外，Gliotoxin对腹膜和肺泡啮齿动物巨噬细胞、人外周血单核细胞、小鼠原代成纤维细胞和L929细胞黏附于塑料表面有不同程度的抑制作用。电子显微镜证实了Gliotoxin对啮齿动物巨噬细胞吞噬碳颗粒的抑制作用，同时也揭示了Gliotoxin诱导的形态学改变。Gliotoxin选择性地影响啮齿动物来源细胞的葡萄糖代谢和大分子合成，并抑制人多形核中性粒细胞产生H2O2的基础速率；驻留腹膜巨噬细胞的杀菌活性也被消除。Gliotoxin诱导的这些细胞功能和代谢变化发生在远低于一般毒性水平的浓度下。
