Mapp C, Hartiala J, Frick O L, Shields R L, Gold W M
J Appl Physiol (1985). 1986 Oct;61(4):1467-74. doi: 10.1152/jappl.1986.61.4.1467.
The relationship between airway responsiveness to inhaled antigen and histamine, immunologic release of lung histamine, immunologic responsiveness of skin, and specific immunoglobulin E (IgE) antibodies were examined in 11 inbred allergic dogs immunized with extracts of ragweed and grass and 5 nonimmunized control dogs from the same colony. Airway responsiveness to antigen and histamine was characterized by the doses that increased the airflow resistance of the total respiratory system to twice the control values (ED200). Highly significant correlations were found between airway responsiveness and cutaneous responsiveness to antigen and other immunologic characteristics (e.g., IgE and histamine released from lung by inhaled antigen) in all dogs. In ragweed-sensitized dogs, there was an inverse correlation between immunologic responsiveness (reflected by the cutaneous response to antigen and histamine released from lung by inhaled antigen) and nonimmunologic responsiveness of airways (histamine ED200: r = 0.73, P less than 0.05 and r = 0.75, P less than 0.01, respectively). Antigen ED200 was also correlated with histamine release from lung after antigen inhalation (r = 0.74; P less than 0.01). We conclude that airway reactions to inhaled antigen in allergic dogs are dependent not only on immunologic factors but also on the degree of nonimmunologic airway responsiveness to histamine and that these factors are correlated inversely.
在11只经豚草和草提取物免疫的近交系过敏性犬以及来自同一犬群的5只未免疫对照犬中，研究了气道对吸入抗原和组胺的反应性、肺组胺的免疫释放、皮肤的免疫反应性以及特异性免疫球蛋白E（IgE）抗体之间的关系。气道对抗原和组胺的反应性通过使整个呼吸系统气流阻力增加至对照值两倍的剂量（ED200）来表征。在所有犬中，均发现气道反应性与皮肤对抗原的反应性以及其他免疫特征（例如，IgE和吸入抗原后从肺中释放的组胺）之间存在高度显著的相关性。在豚草致敏犬中，免疫反应性（以皮肤对抗原的反应和吸入抗原后从肺中释放的组胺来反映）与气道的非免疫反应性（组胺ED200：r分别为0.73，P<0.05和r为0.75，P<0.01）之间存在负相关。抗原ED200也与吸入抗原后肺中组胺的释放相关（r = 0.74；P<0.01）。我们得出结论，过敏性犬对吸入抗原的气道反应不仅取决于免疫因素，还取决于气道对组胺的非免疫反应程度，并且这些因素呈负相关。
