University of Rochester School of Medicine, 601 Elmwood Avenue, Box 693, Rochester, NY 14642, USA.
Best Pract Res Clin Haematol. 2013 Sep;26(3):249-52. doi: 10.1016/j.beha.2013.10.004. Epub 2013 Oct 16.
Over the last 10 years, progress has been made in understanding the relationship between hematopoietic stem cells and their microenvironment, or niche. Increased knowledge of the microenvironment and its effects on hematopoiesis and leukemogenesis based on murine models may lead to the identification of relevant new therapeutic targets for leukemia. In particular, the chemokine CCL3 has potential as a mediator of leukemia-induced microenvironmental changes, as it has been found to be increased in human acute myeloid leukemia.
在过去的 10 年中，人们对造血干细胞与其微环境（或龛）之间的关系有了更多的了解。基于鼠类模型对微环境及其对造血和白血病发生的影响的深入了解，可能会发现白血病相关的新治疗靶点。特别是趋化因子 CCL3 作为白血病诱导的微环境变化的介质具有潜在的作用，因为它在人类急性髓细胞白血病中发现增加。
