Chen Ming, Li Yi, Huang Xiang, Gu Ya, Li Shang, Yin Pengbin, Zhang Licheng, Tang Peifu
Department of Orthopedics, Chinese PLA General Hospital, Beijing, China.
National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing, China.
Bone Res. 2021 Mar 22;9(1):21. doi: 10.1038/s41413-021-00138-0.
Angiogenesis and osteogenesis are coupled. However, the cellular and molecular regulation of these processes remains to be further investigated. Both tissues have recently been recognized as endocrine organs, which has stimulated research interest in the screening and functional identification of novel paracrine factors from both tissues. This review aims to elaborate on the novelty and significance of endocrine regulatory loops between bone and the vasculature. In addition, research progress related to the bone vasculature, vessel-related skeletal diseases, pathological conditions, and angiogenesis-targeted therapeutic strategies are also summarized. With respect to future perspectives, new techniques such as single-cell sequencing, which can be used to show the cellular diversity and plasticity of both tissues, are facilitating progress in this field. Moreover, extracellular vesicle-mediated nuclear acid communication deserves further investigation. In conclusion, a deeper understanding of the cellular and molecular regulation of angiogenesis and osteogenesis coupling may offer an opportunity to identify new therapeutic targets.
血管生成与骨生成相互关联。然而，这些过程的细胞和分子调控仍有待进一步研究。最近，这两种组织都被认为是内分泌器官，这激发了人们对从这两种组织中筛选新型旁分泌因子并进行功能鉴定的研究兴趣。本综述旨在阐述骨骼与脉管系统之间内分泌调节回路的新颖性和重要性。此外，还总结了与骨脉管系统、血管相关骨骼疾病、病理状况以及血管生成靶向治疗策略相关的研究进展。关于未来展望，诸如单细胞测序等新技术可用于展示这两种组织的细胞多样性和可塑性，正在推动该领域的进展。此外，细胞外囊泡介导的核酸通讯值得进一步研究。总之，更深入地了解血管生成与骨生成偶联的细胞和分子调控可能为确定新的治疗靶点提供契机。
