Baker H
J Comp Neurol. 1986 Oct 8;252(2):206-26. doi: 10.1002/cne.902520206.
These studies document species differences in the distribution of the peptide substance P and the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH) within a central nervous system region of a number of mammalian species including the mouse, rat, guinea pig, rabbit, cat, and two species of hamster (Chinese and Syrian). Substance P-containing neuronal perikarya were observed in the main olfactory bulb (MOB) of both species of the hamster, but not in the MOB of the other species examined. In the accessory olfactory bulb (AOB), however, neuronal staining was observed in all species except the mouse. The number of stained somata and their intensity varied such that label was most prominent in the rat followed in decreasing order by the rabbit, guinea pig, cat, and hamster. The mouse displayed no perikaryal staining. Stained somata in AOB were found in the internal granule cell layer with dendritic processes ramifying through the internal plexiform layer to arborize within the mitral cell layer. The distribution of substance P-stained neurons in the MOB also differed between the two hamster strains. In the Syrian hamster, neurons were primarily juxtaglomerular. In the Chinese hamster, labeled perikarya were found in both the juxtaglomerular region and within the superficial aspect of the external plexiform layer (EPL). The mean longest diameter of the majority of substance P-labeled neurons in both species was greater than 10 micron, suggesting that they were tufted cells. Those in the EPL of the Chinese hamster were the largest (17 micron). Species differences also were observed in the distribution of substance P-positive axons and terminals within the MOB. Label was distributed primarily in the internal granule cell layer of the Syrian hamster and the internal plexiform layer of the Chinese hamster. Tyrosine hydroxylase staining was similar among species with the exception of the Syrian hamster. In the latter species, an additional large population of neurons was found within the external plexiform layer. In all other species, TH-stained neurons were found scattered throughout the MOB and occasionally the AOB but were not numerous in the EPL. Although most TH neurons were larger than 10 microns, in all species a population of smaller TH cells was observed primarily in the glomerular layer, suggesting that most neurons labeled with TH are tufted cells but that some may be periglomerular cells.(ABSTRACT TRUNCATED AT 400 WORDS)
这些研究记录了多种哺乳动物（包括小鼠、大鼠、豚鼠、兔子、猫以及两种仓鼠——中国仓鼠和叙利亚仓鼠）中枢神经系统区域内肽物质P和儿茶酚胺合成酶酪氨酸羟化酶（TH）分布的物种差异。在两种仓鼠的主嗅球（MOB）中均观察到含有物质P的神经元胞体，但在所检查的其他物种的主嗅球中未观察到。然而，在副嗅球（AOB）中，除小鼠外的所有物种均观察到神经元染色。染色胞体的数量及其强度各不相同，其中大鼠的标记最为明显，其次依次为兔子、豚鼠、猫和仓鼠。小鼠未显示胞体染色。在AOB中，染色胞体位于内颗粒细胞层，其树突状突起穿过内丛状层，在二尖瓣细胞层内形成分支。两种仓鼠品系在MOB中物质P染色神经元的分布也有所不同。在叙利亚仓鼠中，神经元主要位于近肾小球区。在中国仓鼠中，标记的胞体见于近肾小球区和外丛状层（EPL）的浅层。两种仓鼠中大多数物质P标记神经元的平均最长直径均大于10微米，表明它们是簇状细胞。中国仓鼠EPL中的神经元最大（17微米）。在MOB内物质P阳性轴突和终末的分布也观察到物种差异。标记主要分布在叙利亚仓鼠的内颗粒细胞层和中国仓鼠的内丛状层。除叙利亚仓鼠外，各物种的酪氨酸羟化酶染色相似。在叙利亚仓鼠中，在外丛状层内发现了另外一大群神经元。在所有其他物种中，TH染色的神经元散在于整个MOB中，偶尔也见于AOB，但在EPL中数量不多。尽管大多数TH神经元大于10微米，但在所有物种中，主要在肾小球层观察到一群较小的TH细胞，这表明大多数用TH标记的神经元是簇状细胞，但有些可能是近肾小球细胞。（摘要截短于400字）
