Phytochemistry Research Laboratories Department of Pharmacy (Pharmaceutical Chemistry), University of Strathclyde, G1 1XW, Glasgow, Scotland.
J Chem Ecol. 1985 Sep;11(9):1323-32. doi: 10.1007/BF01024119.
The biochemical basis for considering tannins as digestion inhibitors has been reexamined. Both stimulatory and inhibitory effects of tannins on tryptic hydrolysis are reported. We show how stimulation may result from tannin-induced structural changes in the substrate protein, effectively denaturing it. The surfactant and bile constituent cholic acid also produced similar stimulatory effects. These results have considerable implications for normal digestive physiology as well as for the impact of tannins on argicultural and natural herbivore populations.
单宁作为消化抑制剂的生化基础已被重新审视。单宁对胰蛋白酶水解的刺激和抑制作用都有报道。我们展示了单宁如何通过诱导底物蛋白的结构变化来刺激，从而有效地使它变性。表面活性剂和胆酸等胆汁成分也产生了类似的刺激作用。这些结果对正常消化生理学以及单宁对农业和自然食草动物种群的影响都有重要意义。
