Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Ciencias, Universidad de Santiago de Compostela, 27002 Lugo, Spain.
Pharmaceutics. 2011 Aug 26;3(3):538-71. doi: 10.3390/pharmaceutics3030538.
In the treatment of intracanal and periodontal infections, the local application of antibiotics and other therapeutic agents in the root canal or in periodontal pockets may be a promising approach to achieve sustained drug release, high antimicrobial activity and low systemic side effects. Microparticles made from biodegradable polymers have been reported to be an effective means of delivering antibacterial drugs in endodontic and periodontal therapy. The aim of this review article is to assess recent therapeutic strategies in which biocompatible microparticles are used for effective management of periodontal and endodontic diseases. In vitro and in vivo studies that have investigated the biocompatibility or efficacy of certain microparticle formulations and devices are presented. Future directions in the application of microencapsulation techniques in endodontic and periodontal therapies are discussed.
在治疗根管内和牙周感染方面，在根管内或牙周袋内局部应用抗生素和其他治疗剂可能是一种很有前途的方法，可以实现持续的药物释放、高抗菌活性和低全身副作用。已报道由可生物降解聚合物制成的微球是在牙髓病学和牙周病学治疗中递送抗菌药物的有效手段。本文旨在评估生物相容性微球在有效管理牙周和牙髓疾病方面的最新治疗策略。本文介绍了研究特定微球制剂和装置的生物相容性或疗效的体外和体内研究。讨论了微囊化技术在牙髓病学和牙周病学治疗中的应用的未来方向。
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