Fratila Dragos Nicolae, Virvescu Dragos Ioan, Luchian Ionut, Hancianu Monica, Baciu Elena Raluca, Butnaru Oana, Budala Dana Gabriela
Department of Oral Diagnosis, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Department of Dental Materials, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Gels. 2024 Oct 16;10(10):661. doi: 10.3390/gels10100661.
This study explores the recent advances of and functional insights into hydrogel composites, materials that have gained significant attention for their versatile applications across various fields, including contemporary dentistry. Hydrogels, known for their high water content and biocompatibility, are inherently soft but often limited by mechanical fragility. Key areas of focus include the customization of hydrogel composites for biomedical applications, such as drug delivery systems, wound dressings, and tissue engineering scaffolds, where improved mechanical properties and bioactivity are critical. In dentistry, hydrogels are utilized for drug delivery systems targeting oral diseases, dental adhesives, and periodontal therapies due to their ability to adhere to the mucosa, provide localized treatment, and support tissue regeneration. Their unique properties, such as mucoadhesion, controlled drug release, and stimuli responsiveness, make them ideal candidates for treating oral conditions. This review highlights both experimental breakthroughs and theoretical insights into the structure-property relationships within hydrogel composites, aiming to guide future developments in the design and application of these multifunctional materials in dentistry. Ultimately, hydrogel composites represent a promising frontier for advancing materials science with far-reaching implications in healthcare, environmental technology, and beyond.
本研究探讨了水凝胶复合材料的最新进展及其功能见解。水凝胶复合材料因其在包括当代牙科在内的各个领域的广泛应用而备受关注。水凝胶以其高含水量和生物相容性而闻名,本质上是柔软的,但常常受到机械脆性的限制。重点关注的关键领域包括为生物医学应用定制水凝胶复合材料,如药物递送系统、伤口敷料和组织工程支架,在这些应用中,改善机械性能和生物活性至关重要。在牙科领域,水凝胶因其能够粘附于粘膜、提供局部治疗并支持组织再生,而被用于针对口腔疾病的药物递送系统、牙科粘合剂和牙周治疗。它们的独特性质,如粘膜粘附性、可控药物释放和刺激响应性,使其成为治疗口腔疾病的理想候选材料。本综述强调了水凝胶复合材料结构-性能关系方面的实验突破和理论见解,旨在指导这些多功能材料在牙科设计和应用中的未来发展。最终,水凝胶复合材料代表了推进材料科学的一个有前景的前沿领域,在医疗保健、环境技术及其他领域具有深远影响。