Mangwala Kimpende Peter, Lusakibanza Mariano, Mesia Kahunu, Tona Lutete, Tits Monique, Angenot Luc, Frédérich Michel, Van Meervelt Luc
Chemistry Department, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven (Heverlee), Belgium.
Acta Crystallogr C. 2013 Dec 15;69(Pt 12):1557-62. doi: 10.1107/S010827011303117X. Epub 2013 Nov 30.
Physalis angulata L., an annual herb from the Solanaceae family, is widely used in popular medicine in tropical countries to treat a variety of diseases. Two products, (X) and (Y), were isolated from a crude CH2Cl2 extract of dried Congolese Physalis angulata L. plants and crystallized from acetone for structure elucidation. Compound (X) corresponds to a physalin B dimer acetone solvate hydrate (2C28H30O9·C3H6O·0.22H2O), while compound (Y) crystallizes as a mixed crystal containing two physalin B molecules which overlap with 5β,6β-epoxyphysalin B, also known as physalin F, and one acetone molecule in the asymmetric unit (1.332C28H30O9·0.668C28H30O10·C3H6O). Antiplasmodial activity, cytotoxic activity and selectivity indices were determined for crude extracts and the two isolated products (X) and (Y).
酸浆属植物酸浆，是一种茄科一年生草本植物，在热带国家被广泛用于民间医学治疗多种疾病。从刚果干燥酸浆属植物的二氯甲烷粗提物中分离出两种产物（X）和（Y），并从丙酮中结晶以进行结构解析。化合物（X）为酸浆苦素B二聚体丙酮溶剂化物水合物（2C₂₈H₃₀O₉·C₃H₆O·0.22H₂O），而化合物（Y）结晶为一种混合晶体，在不对称单元中含有两个与5β,6β-环氧酸浆苦素B（也称为酸浆苦素F）重叠的酸浆苦素B分子和一个丙酮分子（1.332C₂₈H₃₀O₉·0.668C₂₈H₃₀O₁₀·C₃H₆O）。对粗提物以及两种分离产物（X）和（Y）测定了抗疟活性、细胞毒性活性和选择性指数。
