Laboratory of Natural Products, Chulabhorn Research Institute, Bangkok, Thailand.
Chulabhorn Graduate Institute, Chemical Biology Program, Chulabhorn Royal Academy, Bangkok, Thailand.
Nat Prod Res. 2020 Apr;34(8):1097-1104. doi: 10.1080/14786419.2018.1550766. Epub 2019 Jan 8.
A new 22,26- physalin, physalin XI () together with 5 known compounds, were isolated from the dichloromethane extract of L. The structure of isolated compounds was elucidated by spectroscopic analysis. The effects of isolated compounds on cytotoxicity were investigated. Compound was assessed for its cytotoxicity against cancer cell lines (HepG2, HeLa, HuCCA-1, T47-D and A-549) and a normal cell line (MRC-5), and the result showed that it has no activity. Compounds and are highly toxic to H69AR and MDA-MB-23 cell lines. This property appears to be related to the presence of their conjugated double bond or epoxy groups and is a more reliable indication of toxicity than substitution on C(5)-C(6).
从地钱中分离得到一个新的 22,26-Physalin（physalin XI()），并与 5 个已知化合物一起进行分离鉴定，利用波谱数据分析鉴定了化合物的结构。对分离得到的化合物进行了体外抗肿瘤活性实验，结果表明化合物 对 HepG2、HeLa、HuCCA-1、T47-D 和 A-549 肿瘤细胞株和正常细胞株 MRC-5 均无活性，化合物 、对 H69AR 和 MDA-MB-23 细胞株有较强的毒性，这一性质似乎与它们的共轭双键或环氧基团有关，且在 C(5)-C(6) 上取代比这两者更能说明毒性。
