LigSearch：一个基于知识的网络服务器，用于识别蛋白质靶点可能的配体。
LigSearch: a knowledge-based web server to identify likely ligands for a protein target.
作者信息
de Beer Tjaart A P, Laskowski Roman A, Duban Mark-Eugene, Chan A W Edith, Anderson Wayne F, Thornton Janet M
机构信息
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, England.
出版信息
Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2395-402. doi: 10.1107/S0907444913022294. Epub 2013 Nov 19.
Identifying which ligands might bind to a protein before crystallization trials could provide a significant saving in time and resources. LigSearch, a web server aimed at predicting ligands that might bind to and stabilize a given protein, has been developed. Using a protein sequence and/or structure, the system searches against a variety of databases, combining available knowledge, and provides a clustered and ranked output of possible ligands. LigSearch can be accessed at http://www.ebi.ac.uk/thornton-srv/databases/LigSearch.
在进行结晶试验之前确定哪些配体可能与蛋白质结合，可以显著节省时间和资源。已经开发了LigSearch，这是一个旨在预测可能与给定蛋白质结合并使其稳定的配体的网络服务器。该系统利用蛋白质序列和/或结构，针对各种数据库进行搜索，整合现有知识，并提供可能配体的聚类和排序输出。可通过http://www.ebi.ac.uk/thornton-srv/databases/LigSearch访问LigSearch。
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