Zhang Wenting, Gao Kuo, Liu Jingwei, Zhao Huihui, Wang Juan, Li Yubo, Murtaza Ghulam, Chen Jianxin, Wang Wei
Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chao Yang District, Beijing 100029 Peoples Republic of China.
Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
Afr J Tradit Complement Altern Med. 2013 Oct 3;10(6):532-537. doi: 10.4314/ajtcam.v10i6.24.
In recent years, several researches have showed that Buyang Huanwu Decoction (BHD) possesses multiple target points in the intervention of diseases, and has same treatment effects on cerebrovascular diseases and cardiovascular diseases. But, there was no full report about the mechanistic and material basis in Brain-Heart concurrent treatment. The objective of the present study was to examine the pharmacological mechanism of traditional Chinese medicine in the intervention of coronary heart disease and stroke. We combined the HIT, PubChem, David Database resource and the networked pharmacology method to ultimately find out BHD's thirty-five potential brain-heart concurrent treatment target points, and preliminarily reveal BHD's material basis for treatment of cerebrovascular diseases and cardiovascular diseases. Finally, the study provided new information with the guidance meanings.
近年来，多项研究表明，补阳还五汤在疾病干预中具有多个靶点，对脑血管疾病和心血管疾病具有相同的治疗效果。但是，关于脑心同治的作用机制和物质基础尚无完整报道。本研究的目的是探讨中药干预冠心病和中风的药理机制。我们结合HIT、PubChem、David数据库资源和网络药理学方法，最终找出补阳还五汤35个潜在的脑心同治靶点，并初步揭示补阳还五汤治疗脑血管疾病和心血管疾病的物质基础。最后，本研究提供了具有指导意义的新信息。
