College of Korean Medicine, Gachon University, Gyeonggi-do, 13120, South Korea.
College of Korean Medicine, Daejeon University, Daejeon, 34520, South Korea.
J Ethnopharmacol. 2020 Jun 12;255:112765. doi: 10.1016/j.jep.2020.112765. Epub 2020 Mar 11.
Buyang Huanwu Decoction (BHD) is a multi-herbal composition commonly prescribed in the treatment of cerebrovascular diseases such as stroke. Although studies have been conducted at the cellular (in vitro), animal and human (in vivo) level, there was no detailed analysis on how the composition and proportion of BHD is modified according to target diseases.
The purpose of this study is to investigate the composition and proportion of each herb in BHD to summarize how the original BHD was modified according to the target disease.
Electronic literature searches were performed in three databases, collecting sixty-eight studies for the final analysis. The studies were divided into three types: cell studies, animal experiments and clinical trial. In the analysis, the decoction formula including the composition and the weight proportion of the herbs in BHD used in the studies and the target diseases were examined.
The result showed that in cell studies, the targets were mostly cell differentiation, cell injury and immune activation. In animal studies, cerebrovascular diseases such as cerebral ischemia were the most identified target diseases followed by nervous system and cardiovascular diseases. While the proportions of the herbs in BHD used in these studies were in general similar to the original formula, some studies reduced the amount of Astragali Radix to half of the original amount. Modified BHDs were used in four studies for cerebrovascular and peripheral nerve diseases. However, no significant correlation has been observed between the target diseases and the change of the proportion of the herbs in BHD.
The most commonly used formula was the original composition of BHD, and modified BHDs were reported to be used to treat cerebrovascular and nervous diseases. Further studies about the effects of BHD by composition and proportion of herbs are needed in the future.
补阳还五汤（BHD）是一种多草药组合物，常用于治疗中风等脑血管疾病。尽管已经在细胞（体外）、动物和人体（体内）水平进行了研究，但没有详细分析 BHD 的组成和比例如何根据目标疾病进行修改。
本研究的目的是调查 BHD 中每种草药的组成和比例，总结原始 BHD 根据目标疾病进行了哪些修改。
在三个数据库中进行了电子文献检索，共收集了六十八项研究进行最终分析。这些研究分为三类：细胞研究、动物实验和临床试验。在分析中，检查了研究中使用的汤剂配方，包括 BHD 的组成和草药的重量比例，以及目标疾病。
结果表明，在细胞研究中，目标主要是细胞分化、细胞损伤和免疫激活。在动物研究中，脑血管疾病如脑缺血是最确定的目标疾病，其次是神经系统和心血管疾病。而这些研究中使用的 BHD 草药比例与原始配方大致相似，但有些研究将黄芪的用量减少到原始用量的一半。有四项研究使用改良 BHD 治疗脑血管和周围神经疾病。然而，目标疾病与 BHD 草药比例的变化之间没有观察到显著相关性。
最常用的配方是 BHD 的原始组成，据报道改良 BHD 用于治疗脑血管和神经疾病。未来需要进一步研究 BHD 的组成和比例对其疗效的影响。
