Neuroscience Training Program, University of Wisconsin-Madison Madison, WI, USA ; Department of Genetics and Medical Genetics, University of Wisconsin-Madison Madison, WI, USA.
Front Cell Neurosci. 2013 Nov 21;7:222. doi: 10.3389/fncel.2013.00222. eCollection 2013.
Notch is a cell surface receptor that is well known to mediate inter-cellular communication during animal development. Data in the field indicate that it is also involved in the formation of long-term memory (LTM) in the fully developed adults and in memory loss upon neurodegeneration. Our studies in the model organism Drosophila reveal that a non-canonical Notch-protein kinase C activity that plays critical roles in embryonic development also regulates cyclic-AMP response element binding protein during LTM formation in adults. Here we present a perspective on how the various known features of Notch function relate to LTM formation and how they might interface with elements of Wingless/Wnt signaling in this process.
Notch 是一种细胞表面受体，在动物发育过程中，它通过介导细胞间通讯而广为人知。该领域的数据表明，它也参与了完全发育成熟的成年人中长期记忆（LTM）的形成，以及神经退行性病变时记忆的丧失。我们在模式生物果蝇中的研究表明，在胚胎发育中发挥关键作用的非经典 Notch-蛋白激酶 C 活性也在成年 LTM 形成过程中调节环腺苷酸反应元件结合蛋白。在这里，我们提出了一个观点，即 Notch 功能的各种已知特征如何与 LTM 的形成相关，以及它们在这个过程中如何与 Wingless/Wnt 信号转导的元素相互作用。
