Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
PLoS One. 2013 Nov 27;8(11):e81881. doi: 10.1371/journal.pone.0081881. eCollection 2013.
To estimate the seroprevalence of cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella zoster virus (VZV) among pregnant women in Bradford by ethnic group and country of birth.
A stratified random sample of 949 pregnant women enrolled in the Born in Bradford birth cohort was selected to ensure sufficient numbers of White UK born women, Asian UK born women and Asian women born in Asia. Serum samples taken at 24-28 weeks' gestation were tested for CMV IgG, EBV IgG and VZV IgG. Each woman completed a questionnaire which included socio-demographic information.
CMV seroprevalence was 49% among the White British women, 89% among South Asian UK born women and 98% among South Asian women born in South Asia. These differences remained after adjusting for socio-demographic factors. In contrast, VZV seroprevalence was 95% among women born in the UK but significantly lower at 90% among South Asian women born in Asia. EBV seroprevalence was 94% overall and did not vary by ethnic group/country of birth.
Although about half of White British women are at risk of primary CMV infection in pregnancy and the associated increased risk of congenital infection, most congenital CMV infections are likely to be in children born to South Asian women with non-primary infection during pregnancy. South Asian women born in South Asia are at risk of VZV infection during pregnancy which could produce congenital varicella syndrome or perinatal chickenpox. Differences in CMV and VZV seroprevalence by ethnic group and country of birth must be taken into account when universal immunisation against these viruses is contemplated.
通过族裔和出生国，估计布拉德福德孕妇巨细胞病毒（CMV）、爱泼斯坦-巴尔病毒（EBV）和水痘带状疱疹病毒（VZV）的血清流行率。
选择了 949 名参加布拉德福德出生队列的孕妇进行分层随机抽样，以确保有足够数量的英国出生白人、英国出生亚洲人和亚洲出生的亚洲人。在 24-28 周妊娠时采集血清样本，检测 CMV IgG、EBV IgG 和 VZV IgG。每位女性都填写了一份问卷，其中包括社会人口统计学信息。
英国白人女性 CMV 血清流行率为 49%，英国出生的南亚女性为 89%，亚洲出生的南亚女性为 98%。在调整社会人口统计学因素后，这些差异仍然存在。相比之下，在英国出生的女性 VZV 血清流行率为 95%，而在亚洲出生的南亚女性则显著降低至 90%。EBV 血清流行率总体为 94%，且不受族裔/出生国的影响。
尽管约一半的英国白人女性在妊娠期间存在原发性 CMV 感染的风险，并且相关的先天性感染风险增加，但大多数先天性 CMV 感染可能发生在妊娠期间非原发性感染的南亚女性所生的儿童中。在亚洲出生的南亚女性在妊娠期间有感染 VZV 的风险，这可能导致先天性水痘综合征或围产期水痘。在考虑对这些病毒进行普遍免疫时，必须考虑族裔和出生国对 CMV 和 VZV 血清流行率的差异。
