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本文引用的文献

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Development of a liposomal nanodelivery system for nevirapine.奈韦拉平脂质体纳米递药系统的研制。
J Biomed Sci. 2010 Jul 13;17(1):57. doi: 10.1186/1423-0127-17-57.
2
Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability.用于提高长春西汀口服生物利用度的固体脂质纳米粒
J Control Release. 2006 Aug 10;114(1):53-9. doi: 10.1016/j.jconrel.2006.05.010. Epub 2006 May 23.
3
Celecoxib, a cyclooxygenase-2 inhibitor, reduces neointimal hyperplasia through inhibition of Akt signaling.塞来昔布，一种环氧化酶-2抑制剂，通过抑制Akt信号传导来减少新生内膜增生。
Circulation. 2004 Jul 20;110(3):301-8. doi: 10.1161/01.CIR.0000135467.43430.16. Epub 2004 Jul 6.
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Preparation and in vitro evaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol.用于治疗银屑病的药物地蒽酚的脂质体/非离子脂质体递送系统的制备及体外评价
Int J Pharm. 2001 Oct 9;228(1-2):43-52. doi: 10.1016/s0378-5173(01)00810-9.
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Pharmacokinetics of celecoxib in the presence and absence of interferon-induced acute inflammation in the rat: application of a novel HPLC assay.塞来昔布在大鼠存在和不存在干扰素诱导的急性炎症情况下的药代动力学：一种新型高效液相色谱法的应用
J Pharm Pharm Sci. 2001 Jan-Apr;4(1):1-6.

利用薄膜法制备载塞来昔布脂质体

Utilization of thin film method for preparation of celecoxib loaded liposomes.

作者信息

Moghimipour Eskandar, Handali Somayeh

机构信息

Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

出版信息

Adv Pharm Bull. 2012;2(1):93-8. doi: 10.5681/apb.2012.013. Epub 2012 Apr 18.

DOI:10.5681/apb.2012.013
PMID:24312776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3846021/
Abstract

PURPOSE

Celecoxib is nonsteroiddal anti-inflammatory drug that has been used extensively to treat patients with arthritis. The aim of the present study was to formulate and characterize liposomal vesicles loaded with celecoxib.

METHODS

Liposomes were prepared by thin film method using soya lecithin and cholesterol. The release of drug was determined using a dialysis membrane method. Liposomes were characterized by Differential Scanning Calorimetery (DSC), Transmission Electron Microscopy (TEM) and their particle size was also determined.

RESULTS

The results showed that the drug encapsulation efficiency was 67.34% and there was 67.16% release after 0.5, 1, 2, 3, 4, 5, 6, 7, 8 and 24 h. RESULTS of particle size determination showed a mean size of 677nm and nanoparticles were spherical as shown by TEM. The DSC curve of lecithin, cholesterol and celecoxib were different from celecoxib containing liposome.

CONCLUSION

The results of characterization of the vesicles indicated the potential application of celecoxib loaded liposome as carrier system.

摘要

目的

塞来昔布是一种非甾体抗炎药，已被广泛用于治疗关节炎患者。本研究的目的是制备并表征负载塞来昔布的脂质体囊泡。

方法

采用薄膜法，以大豆卵磷脂和胆固醇制备脂质体。使用透析膜法测定药物释放情况。通过差示扫描量热法（DSC）、透射电子显微镜（TEM）对脂质体进行表征，并测定其粒径。

结果

结果显示，药物包封率为67.34%，在0.5、1、2、3、4、5、6、7、8和24小时后释放率为67.16%。粒径测定结果显示平均粒径为677nm，如TEM所示纳米颗粒呈球形。卵磷脂、胆固醇和塞来昔布的DSC曲线与含塞来昔布的脂质体不同。

结论

囊泡的表征结果表明负载塞来昔布的脂质体作为载体系统具有潜在应用价值。