Pakkir Maideen Naina Mohamed, Velayutham Ravichandiran, Manavalan Gobinath
School of Pharmacy, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Chennai-600 117, India.
Adv Pharm Bull. 2012;2(2):179-82. doi: 10.5681/apb.2012.027. Epub 2012 Jun 30.
The objective of the present study was to evaluate the protective effect of methanol extract of Prosopis cineraria (MPC) against N-nitrosodiethylamine (DEN, 200mg/kg) induced Phenobarbital promoted experimental liver tumors in male Wistar rats.
The rats were divided into four groups, each group consisting of six animals. Group 1 served as control animals. Liver tumor was induced in group 2, 3, and 4 and Group 3 animals received MPC 200mg/kg and Group 4 animals received MPC 400mg/kg.
Administration of DEN has brought down the levels of membrane bound enzymes like Na(+)/ K(+) ATPase, Mg(2+) ATPase and Ca(2+)ATPase which were later found to be increased by the administration of Prosopis cineraria (200 and 400mg/kg) in dose dependent manner. The MPC extract also suppressed the levels of glycoproteins like Hexose, Hexosamine and Sialic acid when compared to liver tumor bearing animals.
Our study suggests that MPC may extend its protective role by modulating the levels of membrane bound enzymes and suppressing glycoprotein levels.
本研究的目的是评估灰叶豆甲醇提取物（MPC）对N-亚硝基二乙胺（DEN，200mg/kg）诱导、苯巴比妥促进的雄性Wistar大鼠实验性肝肿瘤的保护作用。
将大鼠分为四组，每组六只动物。第1组作为对照动物。第2、3和4组诱导肝肿瘤，第3组动物接受200mg/kg的MPC，第4组动物接受400mg/kg的MPC。
给予DEN降低了膜结合酶如Na(+)/K(+)ATP酶、Mg(2+)ATP酶和Ca(2+)ATP酶的水平，后来发现给予灰叶豆（200和400mg/kg）后这些酶的水平以剂量依赖方式升高。与荷肝肿瘤动物相比，MPC提取物还抑制了己糖、己糖胺和唾液酸等糖蛋白的水平。
我们的研究表明，MPC可能通过调节膜结合酶水平和抑制糖蛋白水平来发挥其保护作用。
