Jain Ashish, Nayak Satish, Soni Vandana
Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal-462021, India.
Adv Pharm Bull. 2012;2(2):239-44. doi: 10.5681/apb.2012.036. Epub 2012 Aug 15.
The purpose of the present work was to assess iontophoretic permeation of Lisinopril at different current densities and concentrations for development of patient-controlled active transdermal system.
In vitro iontophoretic transdermal delivery of Lisinopril across the pigskin was investigated at three different drug concentrations and three different current densities (0.25- 0.75 mA/cm2) in the donor cell of the diffusion apparatus, using cathodal iontophoresis along with the passive controls.
For passive permeation, the steady state flux significantly increased with the increasing of donor drug concentration. At all concentration levels, iontophoresis considerably increased the permeation rate compared to passive controls. Iontophoretic transport of Lisinopril was to be found increase with current densities. Flux enhancement was highest at the lowest drug load and lowest at the highest drug load.
The obtained results indicate that permeation rate of Lisinopril across the pigskin can be considerably enhanced, controlled or optimized by the use of Iontophoresis technique.
本研究旨在评估不同电流密度和浓度下赖诺普利的离子电渗渗透情况，以开发患者自控主动透皮系统。
在扩散装置的供体池中，使用阴极离子电渗法并设置被动对照组，研究了三种不同药物浓度和三种不同电流密度（0.25 - 0.75 mA/cm²）下赖诺普利经猪皮的体外离子电渗透皮给药情况。
对于被动渗透，稳态通量随供体药物浓度的增加而显著增加。在所有浓度水平下，与被动对照组相比，离子电渗法显著提高了渗透速率。赖诺普利的离子电渗转运随电流密度增加而增加。通量增强在最低药物负载时最高，在最高药物负载时最低。
所得结果表明，通过使用离子电渗技术，赖诺普利经猪皮的渗透速率可得到显著提高、控制或优化。
