放射治疗中纳米金颗粒的制备、物理化学表征及性能评估
Preparation, physicochemical characterization and performance evaluation of gold nanoparticles in radiotherapy.
作者信息
Kamiar Ali, Ghotalou Reza, Vali Zadeh Hadi
机构信息
Faculty of Pharmacy, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Adv Pharm Bull. 2013;3(2):425-8. doi: 10.5681/apb.2013.068. Epub 2013 Aug 20.
PURPOSE
The aim of the present study was preparation, physicochemical characterization and performance evaluation of gold nanoparticles (GNPs) in radiotherapy. Another objective was the investigation of anti-bacterial efficacy of gold nanoparticle against E. coli clinical strains.
METHODS
Gold nanoparticles prepared by controlled reduction of an aqueous HAuCl4 solution using Tri sodium citrate. Particle size analysis and Transmission electron microscopy were used for physicochemical characterization. Polymer gel dosimetry was used for evaluation of the enhancement of absorbed dose. Diffusion method in agar media was used for investigation of anti-bacterial effect.
RESULTS
Gold nanoparticles synthesized in size range from 57 nm to 346 nm by planning different formulation. Gold nanoparticle in 57 nm size increased radiation dose effectiveness with the magnitude of about 21 %. At the concentration of 400 ppm, Nano gold exhibited significant anti-bacterial effect against E. coli clinical strains.
CONCLUSION
It is concluded that gold nanoparticles can be applied as dose enhancer in radiotherapy. The Investigation of anti-bacterial efficacy showed that gold nanoparticle had significant effect against E. coli clinical strains.
目的
本研究的目的是制备用于放射治疗的金纳米颗粒（GNPs），对其进行物理化学表征并评估其性能。另一个目标是研究金纳米颗粒对大肠杆菌临床菌株的抗菌效果。
方法
通过用柠檬酸钠控制还原氯金酸水溶液来制备金纳米颗粒。使用粒度分析和透射电子显微镜进行物理化学表征。使用聚合物凝胶剂量测定法评估吸收剂量的增强情况。采用琼脂培养基中的扩散法研究抗菌效果。
结果
通过设计不同配方合成了尺寸范围为57纳米至346纳米的金纳米颗粒。57纳米尺寸的金纳米颗粒使辐射剂量有效性提高了约21%。在400 ppm的浓度下，纳米金对大肠杆菌临床菌株表现出显著的抗菌效果。
结论
得出结论，金纳米颗粒可作为放射治疗中的剂量增强剂应用。对抗菌效果的研究表明，金纳米颗粒对大肠杆菌临床菌株有显著作用。
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