Loginova N P, Chertvetnykh V A, Khromtsova G A
Arkh Patol. 2013 Jul-Aug;75(4):9-14.
The paper gives the results of morphological and immunohistochemical studies of the thymus in congenital hypoxia induced by the intrauterine development of heart diseases. The morphological changes in the thymic structure have been found to depend on the complicacy of the heart defect determining the degree of hypoxia. There are significant thymic structural changes manifesting themselves as disorders of the epithelial stroma. Its destruction areas exhibit activated fibroblastic differon that positively responds to vimentin and CD34. Increased resistance of lymphocytes to apoptosis has been ascertained and their proliferative properties determined. There is a progressive accumulation of the antiapoptotic protein Bcl-2 in the cytoplasm of thymocytes in the cortex of a thymic lobe and a decrease in Ki-67 expression in the lymphocytes in the thymic lobes, especially in cases of severe heart defects.
本文给出了因先天性心脏病宫内发育所致先天性缺氧时胸腺的形态学和免疫组织化学研究结果。已发现胸腺结构的形态学变化取决于决定缺氧程度的心脏缺陷的复杂性。存在显著的胸腺结构变化，表现为上皮基质紊乱。其破坏区域显示出对波形蛋白和CD34呈阳性反应的活化成纤维细胞差异群。已确定淋巴细胞对凋亡的抵抗力增加，并测定了其增殖特性。在胸腺小叶皮质的胸腺细胞胞质中，抗凋亡蛋白Bcl-2逐渐积累，而胸腺小叶中淋巴细胞的Ki-67表达降低，尤其是在严重心脏缺陷的情况下。
