生化标志物的使用是一个比自我报告指标更好的预测结果的指标，在一个应急管理戒烟模拟研究中。

Biochemical marker of use is a better predictor of outcomes than self-report metrics in a contingency management smoking cessation analog study.

机构信息

College of Nursing, Washington State University, Spokane, Washington; Program of Excellence in the Addictions, Washington State University, Spokane, Washington; Program of Excellence in Rural Mental Health and Substance Abuse Treatment, Washington State University, Spokane, Washington; Translational Addiction Research Center, Washington State University, Spokane, Washington.

出版信息

Am J Addict. 2014 Jan-Feb;23(1):15-20. doi: 10.1111/j.1521-0391.2013.12059.x. Epub 2013 May 24.

DOI:10.1111/j.1521-0391.2013.12059.x

PMID:24313236

Abstract

BACKGROUND AND OBJECTIVES

This investigation compared cotinine (primary metabolite of nicotine) at study intake to self-report metrics (e.g., Fagerstrom Test of Nicotine Dependence [FTND]) and assessed their relative ability to predict smoking outcomes.

METHODS

We used data from an analog model of contingency management for cigarette smoking. Non-treatment seeking participants (N = 103) could earn money in exchange for provision of a negative carbon monoxide (CO) sample indicating smoking abstinence, but were otherwise not motivated to quit. We used intake cotinine, FTND, percent of friends who smoke, and years smoked to predict longitudinal CO and attendance, time-to-first positive CO submission, and additional cross-sectional outcomes.

RESULTS

Intake cotinine was consistently predictive (p < .05) of all outcomes (e.g., longitudinal CO and attendance, 100% abstinence, time-to-first positive CO sample), while years smoked was the only self-report metric that demonstrated any predictive ability.

CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE

Cotinine could be more informative for tailoring behavioral treatments compared to self-report measures.

摘要

背景和目的

本研究将研究摄入时的可替宁（尼古丁的主要代谢物）与自我报告指标（例如，尼古丁依赖测试 [FTND]）进行比较，并评估它们预测吸烟结果的相对能力。

方法

我们使用了吸烟行为模拟条件管理的研究数据。非治疗寻求参与者（N=103）可以通过提供阴性一氧化碳（CO）样本来赚取金钱，表明他们已经戒烟，但除此之外，他们并没有戒烟的动力。我们使用摄入时的可替宁、FTND、吸烟朋友的比例和吸烟年数来预测纵向 CO 和出勤率、首次阳性 CO 提交的时间以及其他横向结果。