Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota; Center for Sleep Medicine, Mayo Clinic, Rochester, Minnesota.
Am J Addict. 2014 Jan-Feb;23(1):21-6. doi: 10.1111/j.1521-0391.2013.12056.x. Epub 2013 Jun 6.
Understanding the course and determinants of sleep disturbances in alcoholic patients may help identify patients at high risk of persistent sleep problems, relapse and guide treatment interventions.
We prospectively administered the Pittsburgh Sleep Quality Index (PSQI) to all patients (N = 196) admitted to a 1-month residential treatment program. Our analysis excluded patients with active drug abuse/dependence. Demographic data, psychiatric diagnoses, Patient Health Questionnaire-9 (PHQ-9), Alcohol Use Disorders Identification Test (AUDIT) and Inventory of Drug Taking Situations (IDTS) scores were obtained. Univariate and logistic regression analyses were performed using sex, age, hazardous alcohol use, PHQ-9 scores, hypnotic use, and use of alcohol as a hypnotic as correlates to admission PSQI scores and improvement in PSQI scores.
A total of 119 alcoholic patients met inclusion criteria (mean age 50.6 ± 13.2 years). The rates of sleep disturbances at admission and discharge were 69.3% and 49.1%, respectively. Self report of using alcohol to fall asleep and use of hypnotics were associated with elevated PSQI scores. Total PSQI scores improved over 4 weeks (p < .001). Change in PSQI scores was not effected by gender, use of hypnotics, hazardous alcohol use, use of alcohol as a hypnotic or co-morbid psychiatric diagnosis. Older age predicted improvement in PSQI scores in patients with sleep disturbances (p = .004).
While a large proportion of alcoholics had sleep disturbances upon admission and at discharge from a residential treatment program, only older age was associated with improvements in sleep disturbances during early alcohol recovery.
了解酒精患者睡眠障碍的过程和决定因素,可能有助于识别存在持续性睡眠问题、复发风险高的患者,并指导治疗干预措施。
我们前瞻性地对所有(N=196)进入为期 1 个月的住院治疗项目的患者使用匹兹堡睡眠质量指数(PSQI)进行评估。我们的分析排除了有活跃药物滥用/依赖的患者。收集人口统计学数据、精神科诊断、患者健康问卷-9(PHQ-9)、酒精使用障碍识别测试(AUDIT)和药物使用情况量表(IDTS)评分。使用性别、年龄、危险饮酒、PHQ-9 评分、催眠药物使用以及将酒精作为催眠药物,分析与入院 PSQI 评分和 PSQI 评分改善相关的因素。
共有 119 名酒精患者符合纳入标准(平均年龄 50.6±13.2 岁)。入院和出院时睡眠障碍的发生率分别为 69.3%和 49.1%。报告使用酒精入睡和使用催眠药物与 PSQI 评分升高相关。总 PSQI 评分在 4 周内改善(p<.001)。PSQI 评分的变化不受性别、催眠药物使用、危险饮酒、将酒精作为催眠药物或共病精神科诊断的影响。年龄较大的患者睡眠障碍改善(p=0.004)。
尽管很大一部分酒精患者在住院治疗项目入院时和出院时存在睡眠障碍,但只有年龄较大与酒精戒断早期睡眠障碍的改善有关。