Anghileri L J, Marchal C, Matrat M, Crone-Escanye M C, Robert J
Neoplasma. 1986;33(5):603-8.
Ruthenium red (RR) is taken up by DS sarcoma cells as a linear function of its concentration. Higher temperatures produce a higher uptake. This increased uptake is coincident with an augmentation of Trypan blue inclusion. A diminution of calcium transport in the presence of RR is observed at hyperthermia, and its uptake is not linear but presents a plateau for all temperatures and concentrations. RR-cell membrane interaction seems to produce two different effects: an early blocking of calcium transport, and a later change of the physicochemical characteristics of the plasma membrane. On the colony forming ability of CA1 cell RR shows clearly an intrinsic toxic effect, and when present during hyperthermia a low but significant enhancement of tumor cells mortality.
钌红（RR）被DS肉瘤细胞摄取，摄取量是其浓度的线性函数。温度升高会导致摄取量增加。这种摄取量的增加与台盼蓝摄取的增加同时出现。在热疗时，观察到在钌红存在的情况下钙转运减少，并且其摄取不是线性的，而是在所有温度和浓度下都呈现出一个平台期。RR与细胞膜的相互作用似乎产生了两种不同的效应：早期阻断钙转运，以及后期改变质膜的物理化学特性。关于CA1细胞的集落形成能力，钌红明显显示出内在的毒性作用，并且在热疗期间存在时，肿瘤细胞死亡率有低但显著的提高。
