Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei;
J Neurosurg. 2014 Mar;120(3):655-61. doi: 10.3171/2013.10.JNS131357. Epub 2013 Dec 6.
Evidence suggests that hormones play a role in modifying both uterine myoma (UM) and meningioma. A number of studies have observed the positive association between these diseases. The aim of the current population-based study was to determine if women with UM are at a higher risk for meningioma.
The authors used data from the National Health Insurance system of Taiwan for the study. The UM cohort contained 281,244 women. Each woman was randomly frequency-matched with 4 women without UM, based on age, index year of diagnosis, occupation, urbanization (urbanization level was categorized by the population density of the residential area into 4 levels, with Level 1 as the most urbanized and Level 4 as the least urbanized), and comorbidity, to form the control cohort. Cox's proportional hazard regression analysis was conducted to estimate the influence of UM on the meningioma risk.
Among women with UM, the risk of developing meningioma was significantly higher (45%) than among women without UM (95% CI 1.23-1.70). The same phenomenon was observed among most age groups, but a significant difference was only seen in the middle-age range. For women with UM, further analysis did not show a significant change after myomectomy. The cumulative incidence of meningioma between groups with and without UM differed over time.
The nationwide population-based cohort study found that Taiwanese women with UM are at higher risk for developing meningioma.
有证据表明，激素在调节子宫肌瘤（UM）和脑膜瘤方面发挥作用。许多研究观察到这两种疾病之间存在正相关关系。本基于人群的研究旨在确定患有 UM 的女性患脑膜瘤的风险是否更高。
作者使用了来自台湾全民健康保险系统的数据进行研究。UM 队列包含 281244 名女性。每位女性都根据年龄、诊断指数年、职业、城市化程度（按居住区域的人口密度分为 4 个等级，等级 1 最城市化，等级 4 最不城市化）和合并症与 4 名无 UM 的女性进行随机频数匹配，形成对照组。采用 Cox 比例风险回归分析估计 UM 对脑膜瘤风险的影响。
在患有 UM 的女性中，患脑膜瘤的风险明显较高（45%）（95%CI 1.23-1.70）。在大多数年龄组中都观察到了同样的现象，但仅在中年范围内存在显著差异。对于患有 UM 的女性，手术后肌瘤切除术的分析结果没有显示出明显变化。两组间脑膜瘤的累积发病率随时间不同而不同。
这项全国性基于人群的队列研究发现，台湾患有 UM 的女性患脑膜瘤的风险更高。
