Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan.
Int J Clin Pract. 2021 May;75(5):e14065. doi: 10.1111/ijcp.14065. Epub 2021 Feb 17.
The rate of lung cancer in female patients is increasing, with different features from male patients being displayed. Hormonal factors could play a role. The association between the development of uterine myoma (UM) and female hormones has also been reported. The relationship between female lung cancer and UM may be due to the effect of female hormones.
Data from 50 711 Taiwanese women with UM were retrieved from the National Health Insurance Research Database between 2000 and 2012. They were propensity-score matched with 50 711 women without UM (control group). A multivariate Cox proportional hazard regression model was used to compare the incidence of lung cancer between groups and to determine the hazard ratio of lung cancer in the UM group.
The risk of lung cancer was significantly higher in women with myoma (adjusted hazard ratio: 1.62, 95% confidence ratio = 1.24-2.12). Stratified analyses demonstrated that the significantly increased risk of lung cancer was more likely to be found in certain groups, such as women who (a) are of younger age, (b) have a mid-level income, (c) have the highest urbanisation level, (d) are office workers and (e) with a longer follow-up period of myoma. Furthermore, myomectomy did not affect the risk pattern.
The results from this nationwide population-based cohort study suggested that UM is associated with a higher risk of developing lung cancer. However, the exact underlying mechanism accounted for this remains unclear, and our findings still need to be verified by further comprehensive studies elsewhere.
女性肺癌的发病率正在增加，其特征与男性患者不同，这可能与激素有关。据报道，子宫肌瘤（UM）的发生与女性激素有关。女性肺癌与 UM 之间的关系可能与女性激素的作用有关。
从 2000 年至 2012 年，从国家健康保险研究数据库中检索了 50711 例患有 UM 的台湾女性患者的数据。将其与 50711 例无 UM 的女性（对照组）进行倾向评分匹配。采用多变量 Cox 比例风险回归模型比较两组肺癌的发病率，并确定 UM 组肺癌的危险比。
患有子宫肌瘤的女性患肺癌的风险明显更高（调整后的危险比：1.62，95%置信比= 1.24-2.12）。分层分析表明，在某些特定人群中，患肺癌的风险增加更为明显，例如年龄较小、收入中等、城市化程度最高、上班族以及患有子宫肌瘤的随访时间较长的女性。此外，子宫肌瘤切除术并不影响这种风险模式。
这项基于全国人群的队列研究结果表明，UM 与发生肺癌的风险增加有关。然而，确切的潜在机制尚不清楚，我们的研究结果仍需要其他地方的进一步综合研究来验证。
