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提示老年头部创伤患者需行颅脑 CT 扫描的风险因素:奥地利试验及与加拿大 CT 头部规则的比较。

Risk factors indicating the need for cranial CT scans in elderly patients with head trauma: an Austrian trial and comparison with the Canadian CT Head Rule.

机构信息

Departments of Trauma Surgery and.

出版信息

J Neurosurg. 2014 Feb;120(2):447-52. doi: 10.3171/2013.10.JNS13726. Epub 2013 Dec 6.

Abstract

OBJECT

This study presents newly defined risk factors for detecting clinically important brain injury requiring neurosurgical intervention and intensive care, and compares it with the Canadian CT Head Rule (CCHR).

METHODS

This prospective cohort study was conducted in a single Austrian Level-I trauma center and enrolled a consecutive sample of mildly head-injured adults who presented to the emergency department with witnessed loss of consciousness, disorientation, or amnesia, and a Glasgow Coma Scale (GCS) score of 13-15. The studied population consisted of a large number of elderly patients living in Vienna. The aim of the study was to investigate risk factors that help to predict the need for immediate cranial CT in patients with mild head trauma.

RESULTS

Among the 12,786 enrolled patients, 1307 received a cranial CT scan. Four hundred eighty-nine patients (37.4%) with a mean age of 63.9 ± 22.8 years had evidence of an acute traumatic intracranial lesion on CT. Three patients (< 0.1%) were admitted to the intensive care unit for neurological observation and received oropharyngeal intubation. Seventeen patients (0.1%) underwent neurosurgical intervention. In 818 patients (62.6%), no evidence of an acute trauma-related lesion was found on CT. Data analysis showed that the presence of at least 1 of the following factors can predict the necessity of cranial CT: amnesia, GCS score, age > 65 years, loss of consciousness, nausea or vomiting, hypocoagulation, dementia or a history of ischemic stroke, anisocoria, skull fracture, and development of a focal neurological deficit. Patients requiring neurosurgical intervention were detected with a sensitivity of 90% and a specificity of 67% by using the authors' analysis. In contrast, the use of the CCHR in these patients detected the need for neurosurgical intervention with a sensitivity of only 80% and a specificity of 72%.

CONCLUSIONS

The use of the suggested parameters proved to be superior in the detection of high-risk patients who sustained a mild head trauma compared with the CCHR rules. Further validation of these results in a multicenter setting is needed. Clinical trial registration no.: NCT00451789 ( ClinicalTrials.gov .).

摘要

目的

本研究提出了新的定义,以确定需要神经外科干预和重症监护的临床重要脑损伤的风险因素,并将其与加拿大 CT 头规则(CCHR)进行比较。

方法

这是一项在奥地利一级创伤中心进行的前瞻性队列研究,纳入了连续的轻度头部受伤的成年患者,这些患者因意识丧失、定向障碍或遗忘且格拉斯哥昏迷量表(GCS)评分为 13-15 而到急诊科就诊。研究人群包括许多居住在维也纳的老年患者。本研究的目的是研究有助于预测轻度头部创伤患者立即行头颅 CT 的风险因素。

结果

在纳入的 12786 例患者中,有 1307 例接受了头颅 CT 扫描。489 例(37.4%)患者的平均年龄为 63.9±22.8 岁,CT 显示有急性创伤性颅内病变。3 例(<0.1%)患者因神经观察需要入住重症监护病房,并接受经口气管插管。17 例(0.1%)患者接受神经外科干预。在 818 例(62.6%)患者中,CT 未见与急性创伤相关的病变。数据分析显示,以下至少 1 种因素的存在可以预测行头颅 CT 的必要性:遗忘症、GCS 评分、年龄>65 岁、意识丧失、恶心或呕吐、低凝状态、痴呆或缺血性脑卒中史、瞳孔不等大、颅骨骨折和出现局灶性神经功能缺损。使用作者的分析方法,需要神经外科干预的患者的敏感性为 90%,特异性为 67%。相比之下,在这些患者中使用 CCHR 检测到需要神经外科干预的敏感性仅为 80%,特异性为 72%。

结论

与 CCHR 规则相比,使用建议的参数在检测轻度头部创伤的高危患者方面表现更优。需要在多中心环境中进一步验证这些结果。临床试验注册号:NCT00451789(ClinicalTrials.gov)。

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