Yoshikawa C, Koike K, Takano F, Sugiur K, Suzuki N
Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa.
Climacteric. 2014 Aug;17(4):370-6. doi: 10.3109/13697137.2013.871695. Epub 2014 Jan 29.
Injections of human placental extract, which is known to play a role in skin regulation, have long been used for the treatment of skin wrinkles and non-healing wounds. Porcine placental extract (PPE), an oral supplement, was recently developed for this purpose. The aim of this study was to assess whether PPE has a positive effect on the improvement of fine wrinkles below the eye in climacteric women.
We first non-invasively measured wrinkle widths with a skin analyzer in a cross-section of 185 healthy adult Japanese women. Next, 44 climacteric women with mild or few climacteric symptoms were enrolled into an open-label, randomized, controlled study of the effect of PPE on wrinkle widths. A retrospective comparison of wrinkle widths in 123 climacteric women with climacteric symptoms with or without PPE treatment was also performed.
Wrinkle widths below the eye in women ≥ 30 years of age were significantly higher than in women 20-29 years of age. Treatment with three capsules of PPE per day was significantly (p < 0.05) effective in reducing wrinkle widths at 24 weeks compared with control subjects. Retrospective analysis showed that subjects treated with three (p < 0.05) and six (p < 0.01) capsules of PPE per day observed a significant reduction in wrinkle widths compared with untreated subjects.
Oral PPE treatment is a possible option for improving the appearance of fine wrinkles below the eye in climacteric women.
人胎盘提取物注射剂长期以来一直用于治疗皮肤皱纹和难愈合伤口，已知其在皮肤调节中发挥作用。猪胎盘提取物（PPE）作为一种口服补充剂，最近为此目的而研发。本研究的目的是评估PPE对改善更年期女性眼下细纹是否有积极作用。
我们首先使用皮肤分析仪对185名健康成年日本女性进行横断面无创测量皱纹宽度。接下来，44名有轻度或少量更年期症状的更年期女性被纳入一项关于PPE对皱纹宽度影响的开放标签、随机对照研究。我们还对123名有或没有接受PPE治疗的有更年期症状的更年期女性的皱纹宽度进行了回顾性比较。
30岁及以上女性的眼下皱纹宽度显著高于20 - 29岁的女性。与对照组相比，每天服用三粒PPE胶囊在24周时显著（p < 0.05）有效减少皱纹宽度。回顾性分析表明，每天服用三粒（p < 0.05）和六粒（p < 0.01）PPE胶囊的受试者与未治疗的受试者相比，皱纹宽度显著减少。
口服PPE治疗可能是改善更年期女性眼下细纹外观的一种选择。
