a Department of Biomedical Engineering, Faculty of Engineering , Tel-Aviv University , Tel-Aviv 69978 , Israel.
J Biomater Sci Polym Ed. 2014;25(4):410-30. doi: 10.1080/09205063.2013.863748. Epub 2013 Dec 9.
Pain is one of the most common patient complaints encountered by health professionals and remains the number one cause of absenteeism and disability. In the current study, analgesic-eluting bioresorbable porous structures prepared using the freeze-drying of inverted emulsions technique were developed and studied. These drug-eluting structures can be used for coating fibers or implants, or for creating standalone films. They are ideal for forming biomedically important structures that can be used for various applications, such as wound dressings that provide controlled release of analgesics to the wound site in addition to their wound dressing role. Our investigation focused on the effects of the inverted emulsion's parameters on the shell microstructure and on the resulting drug-release profile of ibuprofen and bupivacaine. The release profiles of ibuprofen formulations exhibited a diffusion-controlled pattern, ranging from several days to 21 days, whereas bupivacaine formulations exhibited an initial burst release followed by a three-phase release pattern over a period of several weeks. Higher organic to aqueous phase ratios and higher polymer contents reduced the burst release of both drugs and prolonged their release due to lower porosity. Overall, the drug-eluting porous structures loaded with either ibuprofen or bupivacaine demonstrated a promising potential for use in various applications that require pain relief.
疼痛是医疗专业人员经常遇到的最常见的患者抱怨之一，也是缺勤和残疾的首要原因。在当前的研究中，开发并研究了使用反转乳液冷冻干燥技术制备的具有镇痛作用的可生物降解多孔结构。这些药物洗脱结构可用于纤维或植入物的涂层，或用于制造独立的薄膜。它们非常适合形成生物医学上重要的结构，可用于各种应用，例如伤口敷料，除了其作为伤口敷料的作用外，还可以向伤口部位提供镇痛药物的控制释放。我们的研究重点是反转乳液参数对壳层微观结构的影响，以及布洛芬和布比卡因的释放曲线。布洛芬制剂的释放曲线表现出扩散控制模式，范围从几天到 21 天，而布比卡因制剂则表现出初始突释，然后在数周内呈现三相释放模式。较高的有机相与水相的比例和较高的聚合物含量降低了两种药物的突释，并由于较低的孔隙率延长了药物的释放。总的来说，负载布洛芬或布比卡因的药物洗脱多孔结构在需要缓解疼痛的各种应用中具有很大的应用潜力。
