Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL.
Semin Nucl Med. 2014 Jan;44(1):66-75. doi: 10.1053/j.semnuclmed.2013.10.002.
The concept of molecular imaging has taken off over the past 15 years to the point of the renaming of the Society of Nuclear Medicine (Society of Nuclear Medicine and Molecular Imaging) and Journals (European Journal of Nuclear Medicine and Molecular Imaging) and offering of medical fellowships specific to this area of study. Molecular imaging has always been at the core of functional imaging related to nuclear medicine. Even before the phrase molecular imaging came into vogue, radionuclides and radiopharmaceuticals were developed that targeted select physiological processes, proteins, receptor analogs, antibody-antigen interactions, metabolites and specific metabolic pathways. In addition, with the advent of genomic imaging, targeted genomic therapy, and theranostics, a number of novel radiopharmaceuticals for the detection and therapy of specific tumor types based on unique biological and cellular properties of the tumor itself have been realized. However, molecular imaging and therapeutics as well as the concept of theranostics are yet to be fully realized. The purpose of this review article is to present an overview of the translational approaches to targeted molecular imaging with application to some naturally occurring animal models of human disease.
分子成像的概念在过去的 15 年中得到了迅猛发展，以至于核医学领域的学会（核医学学会和分子成像学会）和期刊（欧洲核医学与分子成像杂志）都进行了更名，并提供了专门针对这一研究领域的医学奖学金。分子成像一直是核医学相关功能成像的核心。甚至在分子成像这个短语流行之前，就已经开发出了针对特定生理过程、蛋白质、受体类似物、抗体-抗原相互作用、代谢物和特定代谢途径的放射性药物和放射性药物。此外，随着基因组成像、靶向基因组治疗和治疗学的出现，已经实现了许多基于肿瘤自身独特的生物学和细胞特性的用于检测和治疗特定肿瘤类型的新型放射性药物。然而，分子成像和治疗学以及治疗学的概念尚未完全实现。本文的目的是概述靶向分子成像的转化方法，并应用于一些天然存在的人类疾病动物模型。
