Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands.
Drug Discov Today. 2010 Feb;15(3-4):102-14. doi: 10.1016/j.drudis.2009.12.003. Epub 2009 Dec 24.
Molecular imaging is the visualization, characterization and measurement of biological processes at the molecular and cellular level. In oncology, molecular imaging approaches can be directly applied as translational biomarkers of disease progression. In this article, selected imaging modalities are discussed with respect to this role. Recent studies focusing on emerging imaging biomarkers and new developments in the field are highlighted. Importantly, because ex vivo or tissue-based imaging now represents an important tool in the discovery and validation of oncology biomarkers, special attention is given to this resurgent field.
分子成像就是在分子和细胞水平上对生物过程进行可视化、定性和定量分析。在肿瘤学领域，分子成像方法可以直接作为疾病进展的转化生物标志物。本文讨论了几种成像模式在这方面的作用，重点介绍了新兴的成像生物标志物和该领域的新进展。值得注意的是，由于离体或组织成像现在已经成为发现和验证肿瘤生物标志物的重要工具，因此本文对这一复兴领域给予了特别关注。
