Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD.
Semin Radiat Oncol. 2014 Jan;24(1):54-60. doi: 10.1016/j.semradonc.2013.09.001.
Interest in comparative effectiveness research (CER) has increased dramatically over the past decade, yet perceptions about what comprises CER varies. CER has several attributes relevant to practice and policy: (1) The goal of CER is to inform decisions about health care. (2) Literature synthesis is used in addition to primary research. (3) CER evaluates not only overall outcomes for the population but also evaluates subgroups that may have heterogeneous outcomes. (4) Research places an emphasis on outcomes in the "real-world" settings. (5) Outcomes studied should be relevant to patients. In radiation oncology, where many of the traditional clinical trials are comparative in nature, the line between CER and "traditional" research may be blurred, but an increased emphasis on CER can help to bridge the research enterprise and clinical practice, helping to inform decision making at the patient, clinician, and policy levels.
在过去十年中，人们对比较效果研究（CER）的兴趣显著增加，但对 CER 所包含内容的看法却存在差异。CER 具有与实践和政策相关的几个属性：(1) CER 的目标是为医疗保健决策提供信息。(2) 除了原始研究外，还使用文献综合。(3) CER 不仅评估人群的总体结果，还评估可能具有异质结果的亚组。(4) 研究侧重于“真实世界”环境中的结果。(5) 研究的结果应与患者相关。在放射肿瘤学中，许多传统的临床试验具有比较性，因此 CER 和“传统”研究之间的界限可能会变得模糊，但是对 CER 的重视程度提高有助于弥合研究企业和临床实践之间的差距，有助于在患者、临床医生和政策层面提供决策依据。
