Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, Calif..
Can J Ophthalmol. 2013 Dec;48(6):489-93. doi: 10.1016/j.jcjo.2013.05.009.
To discuss and illustrate the role of ultra-widefield fluorescein angiography (UWFFA) in the diagnosis and management of peripheral retinal vasculitis.
Retrospective case series.
Four consecutive patients in whom UWFFA showed far peripheral vasculitis were included. All patients were seen between May 2011 and May 2012 at the Doheny Eye Institute.
Conventional fluorescein angiogram (FA) images or areas determined by the Early Treatment of Diabetic Retinopathy Study Group protocol for imaging the posterior pole and peripheral retina were superimposed on the UWFFA images. The ability to detect the extent and severity of vasculitis and vascular occlusion using both conventional FA and UWFFA was compared by 2 investigators, and any discrepancies were adjudicated by a third investigator.
In none of the cases was the full extent of vasculitis and capillary occlusion visible in the fields normally portrayed by conventional FA. In contrast, capillary nonperfusion and peripheral vasculitis were detectable by UWFFA in all cases. In 2 cases, the posterior extent of vasculitis could have been detected by conventional FA.
Detection and depiction of the extent and severity of peripheral vascular changes are enhanced with UWFFA, aiding in the management of vasculitis in the retinal periphery.
讨论并阐明超广角荧光素血管造影（UWFFA）在诊断和治疗周边视网膜血管炎中的作用。
回顾性病例系列。
纳入了 4 名连续患者，UWFFA 显示出广泛的周边血管炎。所有患者均于 2011 年 5 月至 2012 年 5 月在 Doheny 眼科研究所就诊。
将传统的荧光素血管造影（FA）图像或由早期糖尿病视网膜病变研究组协议确定的用于成像后极和周边视网膜的区域叠加到 UWFFA 图像上。由 2 名研究人员比较使用传统 FA 和 UWFFA 检测血管炎和血管闭塞的程度和严重程度的能力，并由第 3 名研究人员解决任何差异。
在没有一个病例中，传统 FA 通常描绘的区域中可以看到血管炎和毛细血管闭塞的全部范围。相比之下，在所有病例中，UWFFA 均可检测到毛细血管无灌注和周边血管炎。在 2 个病例中，后部血管炎的范围可能可以通过传统 FA 检测到。
UWFFA 增强了对周边血管变化的程度和严重程度的检测和描述，有助于治疗视网膜周边的血管炎。
