Moorfields Eye Hospital, National Health Service Foundation Trust , London, UK.
Ocul Immunol Inflamm. 2020 Nov 16;28(8):1192-1195. doi: 10.1080/09273948.2020.1758157. Epub 2020 May 29.
: To report a novel peripheral finding in patients with Birdshot retinochoroiditis (BRC) using ultra-widefield fluorescein angiography (UWFFA). : UWFFA images from 90 patients diagnosed with BRC were reviewed. All images were evaluated for the presence of peripheral retinal ischemic changes and ischemia-related complications. : Thirty-six eyes of 24 patients showed features of peripheral ischemia, including 18 eyes with peripheral capillary non-perfusion (CNP), 5 eyes with teleangectasias, with or without microaneurysms, and 13 eyes with both teleangectasias and CNP. None of the 36 eyes with peripheral ischemic changes developed retinal neovascularization following the diagnosis of peripheral ischemia. : Peripheral ischemia may present in eyes with chronic inflammation as seen in BRC but does not seem to progress to neovascular complications. This is likely to be more common than suspected and has now become evident following the advent of UWFFA. : HLA-A29: Human leukocyte antigen - A29; FFA: Fundus fluorescein angiography; OCT: Optical coherence tomography; ICGA: Indocyanine green angiography; UWF: Ultra-wide field; UWFFA: Ultra-wide field fluorescein angiography; CNP: Capillary non-perfusion.
报告鸟枪弹样脉络膜视网膜炎(BCR)患者应用超广角荧光素血管造影(UWFFA)的新的周边发现。
回顾了 90 例诊断为 BRC 的患者的 UWFFA 图像。所有图像均评估了周边视网膜缺血改变和与缺血相关的并发症。
24 例患者的 36 只眼表现出周边缺血特征,包括 18 只眼周边毛细血管无灌注(CNP)、5 只眼伴有或不伴有微动脉瘤的血管扩张、13 只眼同时伴有血管扩张和 CNP。在诊断为周边缺血后,36 只出现周边缺血改变的眼中无一例发生视网膜新生血管化。
在 BCR 等慢性炎症眼中可能出现周边缺血,但似乎不会进展为新生血管并发症。这比我们怀疑的要常见,而且在超广角荧光素血管造影出现后现在已经很明显了。
HLA-A29:人类白细胞抗原-A29;FFA:眼底荧光素血管造影;OCT:光学相干断层扫描;ICGA:吲哚青绿血管造影;UWF:超广角;UWFFA:超广角荧光素血管造影;CNP:毛细血管无灌注。