Lögdberg L, Akerström B, Shevach E M
Scand J Immunol. 1986 Nov;24(5):575-81. doi: 10.1111/j.1365-3083.1986.tb02173.x.
Guinea pig alpha 1-microglobulin (alpha 1-m) was found to exert mitogenic effects on guinea pig lymphocytes, i.e. peritoneal exudate lymphocytes (PEL) or T lymphocytes from regional or mesenteric lymph nodes (LNL). On the other hand, spleen T lymphocytes did not respond to alpha 1-m. Stimulation of LNL required the presence of accessory cells. The stimulatory effect was strain-specific: alpha 1-m clearly induced proliferation of lymphocytes from Strain 2 guinea pigs, whereas Strain 13 lymphocytes responded poorly or not at all. Moreover, alpha 1-m inhibited antigen-driven proliferation of guinea pig lymphocytes. None of the effects described were species-specific, e.g. human alpha 1-m exerted similar effects on the guinea pig lymphocytes. These data indicate that alpha 1-m may be involved in the regulation of lymphocyte activation.
已发现豚鼠α1-微球蛋白（α1-m）对豚鼠淋巴细胞具有促有丝分裂作用，即对腹膜渗出淋巴细胞（PEL）或来自局部或肠系膜淋巴结（LNL）的T淋巴细胞有此作用。另一方面，脾T淋巴细胞对α1-m无反应。刺激LNL需要辅助细胞的存在。这种刺激作用具有品系特异性：α1-m能明显诱导2系豚鼠淋巴细胞增殖，而13系淋巴细胞反应较弱或根本无反应。此外，α1-m抑制豚鼠淋巴细胞的抗原驱动增殖。所述的这些作用均无种属特异性，例如人α1-m对豚鼠淋巴细胞也有类似作用。这些数据表明α1-m可能参与淋巴细胞活化的调节。
