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创新药物的可及性:法国各医院在使用昂贵抗癌药物方面是否存在差异?

Access to innovation: is there a difference in the use of expensive anticancer drugs between French hospitals?

作者信息

Bonastre Julia, Chevalier Julie, Van der Laan Chantal, Delibes Michel, De Pouvourville Gerard

机构信息

Institut Gustave Roussy, Department of Biostatistics and Epidemiology, Health Economics Unit, 114 rue Edouard Vaillant, 94805 Villejuif Cedex, France.

ESSEC Business School, Avenue Bernard Hirsch, BP 50 105, 95 021 Cergy-Pontoise Cedex, France.

出版信息

Health Policy. 2014 Jun;116(2-3):162-9. doi: 10.1016/j.healthpol.2013.11.006. Epub 2013 Nov 20.

Abstract

In DRG-based hospital payment systems, expensive drugs are often funded separately. In France, specific expensive drugs (including a large proportion of anticancer drugs) are fully reimbursed up to national reimbursement tariffs to ensure equity of access. Our objective was to analyse the use of expensive anticancer drugs in public and private hospitals, and between regions. We had access to sales per anticancer drug and per hospital in the year 2008. We used a multilevel model to study the variation in the mean expenditure of expensive anticancer drugs per course of chemotherapy and per hospital. The mean expenditure per course of chemotherapy was €922 [95% CI: 890-954]. At the hospital level, specialisation in chemotherapies for breast cancers was associated with a higher expenditure of anticancer drugs per course for those hospitals with the highest proportion of cancers at this site. There were no differences in the use of expensive drugs between the private and the public hospital sector after controlling for case mix. There were no differences between the mean expenditures per region. The absence of disparities in the use of expensive anticancer drugs between hospitals and regions may indicate that exempting chemotherapies from DRG-based payments and providing additional reimbursement for these drugs has been successful at ensuring equal access to care.

摘要

在基于疾病诊断相关分组(DRG)的医院支付系统中,昂贵药物通常单独获得资金支持。在法国,特定的昂贵药物(包括很大一部分抗癌药物)按照国家报销费率全额报销,以确保医疗服务可及性的公平性。我们的目标是分析公立和私立医院以及不同地区对昂贵抗癌药物的使用情况。我们获取了2008年每种抗癌药物和每家医院的销售数据。我们使用多层次模型来研究每家医院每个化疗疗程中昂贵抗癌药物平均支出的差异。每个化疗疗程的平均支出为922欧元[95%置信区间:890 - 954]。在医院层面,对于乳腺癌化疗有专长的医院,在该部位癌症占比最高的那些医院中,每个疗程的抗癌药物支出更高。在控制病例组合后,私立和公立医院部门在昂贵药物的使用上没有差异。各地区的平均支出也没有差异。医院和地区之间在昂贵抗癌药物使用上不存在差异,这可能表明将化疗排除在基于DRG的支付之外并为这些药物提供额外报销,在确保平等获得医疗服务方面是成功的。

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