Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA.
The Small-Molecule X-ray Crystallography Laboratory, University of Kansas, Lawrence, KS 66047, USA.
Phytochemistry. 2014 Feb;98:232-5. doi: 10.1016/j.phytochem.2013.11.005. Epub 2013 Dec 5.
Withanolides 2,3-dihydrotrechonolide A (1) and 2,3-dihydro-21-hydroxytrechonolide A (2) were isolated along with two known withanolides trechonolide A (3) and jaborosalactone 39 (4) from Jaborosa caulescens var. bipinnatifida (Solanaceae). The structures of 1-2 were elucidated through 2D NMR and other spectroscopic techniques. In addition, the structure of withanolide 1 was confirmed by X-ray crystallographic analysis.
从长柄茄 Jaborosa caulescens var. bipinnatifida（茄科）中分离得到了两种新的 2,3-二氢特雷醇内酯类化合物 2,3-二氢特雷醇内酯 A（1）和 2,3-二氢-21-羟基特雷醇内酯 A（2），以及两种已知的特雷醇内酯类化合物特雷醇内酯 A（3）和 jaborosalactone 39（4）。通过二维 NMR 和其他光谱技术阐明了 1-2 的结构。此外，通过 X 射线晶体学分析确定了 1 的结构。
