Facultad de Ciencias Químicas, Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina.
Phytochemistry. 2012 Apr;76:150-7. doi: 10.1016/j.phytochem.2011.12.018. Epub 2012 Feb 8.
Three withanolides were isolated from the aerial parts of Jaborosa reflexa Phil. Jaborosa cabrerae Barboza yielded five sativolide withanolides (including jaborosalactones R, S, 38, and 39) and two trechonolide withanolides epimeric at C-23 (trechonolide A and jaborosalactone 32). In addition, five derivatives were obtained by chemical derivatization of jaborosalactone 38, and all compounds were fully characterized by 1D and 2D NMR spectroscopic studies. The in vitro antiproliferative activities of the major natural withanolides and the semisynthetic derivatives were examined against HBL-100, HeLa, SW1573, T-47D, and WiDr human solid tumor cancer cell lines. Some chemotaxonomic considerations are discussed.
从 reflexa Phil. 的地上部分中分离出三种羽扇豆烷内酯。Jaborosa cabrerae Barboza 产生了五种 sativolide 羽扇豆烷内酯（包括 jaborosalactones R、S、38 和 39）和两种 C-23 差向异构体的 trechonolide 羽扇豆烷内酯（trechonolide A 和 jaborosalactone 32）。此外，通过 jaborosalactone 38 的化学衍生化获得了五个衍生物，所有化合物均通过 1D 和 2D NMR 光谱研究进行了充分表征。对主要天然羽扇豆烷内酯和半合成衍生物的体外增殖活性进行了研究，以评估其对 HBL-100、HeLa、SW1573、T-47D 和 WiDr 人实体瘤癌细胞系的抑制作用。讨论了一些化学分类学方面的考虑因素。
