Department of Radiology, Washington University, Saint Louis, MO 63130, USA.
Department of Radiology, Washington University, Saint Louis, MO 63130, USA.
J Magn Reson. 2014 Feb;239:139-42. doi: 10.1016/j.jmr.2013.09.019. Epub 2013 Nov 16.
In a recently published paper by Parra-Robles and Wild, the authors challenge the in vivo lung morphometry technique (based on hyperpolarized gas diffusion MRI) developed by our Washington University research group. In this Commentary we demonstrate that the main conclusion of Parra-Robles and Wild, that our MRI-based lung morphometry technique "produces inaccurate estimates of the airway dimensions", does not have any scientific basis and is not in agreement with the considerable body of peer-reviewed scientific reports as well as with Parra-Robles and Wild's own data. On the contrary, our technique has a strong theoretical background, is validated, and provides accurate 3D tomographic information on lung microstructural parameters previously available only from invasive biopsy specimens. This technique has already produced a number of results related to lung morphology and function that were not previously available. In our Commentary we also discuss a number of other incorrect statements in and shortcomings of Parra-Robles and Wild's paper.
在最近发表的一篇由 Parra-Robles 和 Wild 撰写的论文中，作者对我们华盛顿大学研究小组开发的基于超极化气体扩散 MRI 的体内肺形态计量技术提出了质疑。在这篇评论中，我们证明了 Parra-Robles 和 Wild 的主要结论，即我们基于 MRI 的肺形态计量技术“产生不准确的气道尺寸估计”，没有任何科学依据，并且与大量经过同行评审的科学报告以及 Parra-Robles 和 Wild 自己的数据不一致。相反，我们的技术具有坚实的理论基础，经过验证，并提供了以前只能从侵入性活检样本中获得的肺部微观结构参数的准确 3D 断层成像信息。该技术已经产生了一些与肺形态和功能相关的结果，这些结果以前是无法获得的。在我们的评论中，我们还讨论了 Parra-Robles 和 Wild 的论文中的其他一些不正确的陈述和缺点。
