HLA - B POT：B7交叉反应组内的一种新的HLA抗原。

HLA-B POT: a new HLA-antigen within the B7-cross reactive group.

作者信息

Reekers P, van der Beucken M, Andrien M, Beelen J, Mueller-Eckhardt G, Schreuder G M

出版信息

Tissue Antigens. 1986 Sep;28(3):182-9. doi: 10.1111/j.1399-0039.1986.tb00479.x.

DOI:10.1111/j.1399-0039.1986.tb00479.x

Abstract

In this report, a new HLA-B locus antigen is described (tentatively called POT). The antigen has been identified with antisera against the antigens that belong to the B7-cross reacting group. In a collaborative study, based on exchange of cells and sera, it was confirmed by population and family studies that the antigen is distinct from B7, Bw42 or Bw73 and is associated with Bw6. In absorption experiments with EBV-transformed cell lines, the POT-antigens removes preferentially anti-B7, Bw42 and Bw73 activity and to a lesser extent antibodies reactive with the B40 CREG-antigens.

摘要

在本报告中，描述了一种新的HLA - B位点抗原（暂称为POT）。该抗原已通过针对属于B7交叉反应组的抗原的抗血清得以鉴定。在一项基于细胞和血清交换的合作研究中，通过群体和家系研究证实该抗原与B7、Bw42或Bw73不同，且与Bw6相关。在对EB病毒转化细胞系的吸收实验中，POT抗原优先去除抗B7、Bw42和Bw73活性，对与B40 CREG抗原反应的抗体的去除作用较小。