HLA - B SNA抗原：一种属于B5 CREG的与BW6相关的B位点抗原。

HLA-B SNA antigen: a BW6 associated B locus antigen belonging to the B5 CREG.

作者信息

Andrien M, Reekers P, Stordeur P, Vandercruys M, Dupont E

机构信息

Department of Immunology, Hematology and Transfusion, Erasme Hospital, Cliniques Universitaires de Bruxelles, Belgium.

出版信息

Tissue Antigens. 1989 Mar;33(3):400-7. doi: 10.1111/j.1399-0039.1989.tb01683.x.

DOI:10.1111/j.1399-0039.1989.tb01683.x

PMID:2741166

Abstract

A new B locus antigen has been found in members of two unrelated families and in a patient originating from Morocco belonging to the Berber population. A complete analysis has been performed with antisera from the 9th and 10th IHWS defining the B5 CREG antigens. Serology, absorption experiments and family studies indicate that SNA antigen is a Bw6 associated subtype of B5 antigen closely related to but clearly distinct from each of the B5 CREG antigens. One-dimensional isoelectric focusing study (1D-IEF) confirms that the SNA antigen precipitates as a B locus gene product and has an isoelectric point identical to that of Bw52 and one of the charge variants of B51.

摘要

在两个不相关家族的成员以及一名来自摩洛哥柏柏尔族的患者中发现了一种新的B位点抗原。使用第9届和第10届国际人类白细胞抗原研讨会（IHWS）中定义B5 CREG抗原的抗血清进行了全面分析。血清学、吸收实验和家族研究表明，SNA抗原是B5抗原的一种与Bw6相关的亚型，与每个B5 CREG抗原密切相关但明显不同。一维等电聚焦研究（1D-IEF）证实，SNA抗原作为B位点基因产物沉淀，其等电点与Bw52以及B51的一种电荷变体相同。