在一只接受MNU处理的雌性斯普拉格-道利大鼠中观察到肝神经鞘瘤。
A liver schwannoma observed in a female Sprague-Dawley rat treated with MNU.
作者信息
Teixeira-Guedes Catarina Isabel, Faustino-Rocha Ana Isabel, Talhada Daniela, Duarte José Alberto, Ferreira Rita, Seixas Fernanda, Oliveira Paula Alexandra
机构信息
Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport Sciences, University of Porto, Porto, Portugal.
出版信息
Exp Toxicol Pathol. 2014 Mar;66(2-3):125-8. doi: 10.1016/j.etp.2013.11.003. Epub 2013 Dec 4.
BACKGROUND
Schwannoma is a tumor of the nervous system composed by Schwann cells. It can occur naturally in several tissues of the body in both humans and animals. Diaphragmatic hernia can be congenital or acquired and is defined as a protrusion of abdominal viscera into the thoracic cavity.
MATERIALS AND METHODS
The animal was a female rat from an experiment of mammary tumor chemically induced. It was injected with N-methyl-N-nitrosourea (MNU) and died spontaneously at 22 weeks of age.
RESULTS
The animal had a diaphragmatic hernia and a hemorrhagic and multicystic mass in the liver herniated lobule. Microscopically the liver displayed a well circumscribed mass that was a tumor with hemorrhagic areas, necrosis and Antoni A and Antoni B patterns. It also displayed occasional positivity to vimentin and diffuse positivity to S-100 and NSE.
CONCLUSION
The tumor was a schwannoma with the origin in the Glisson's capsule.
背景
神经鞘瘤是一种由施万细胞组成的神经系统肿瘤。它可自然发生于人和动物身体的多个组织中。膈疝可分为先天性或后天性，定义为腹腔脏器突入胸腔。
材料与方法
该动物为一只来自化学诱导乳腺肿瘤实验的雌性大鼠。它被注射了N-甲基-N-亚硝基脲（MNU），并在22周龄时自然死亡。
结果
该动物患有膈疝，肝脏疝出小叶内有一个出血性多囊性肿块。显微镜下，肝脏显示出一个边界清晰的肿块，是一个伴有出血区域、坏死以及Antoni A和Antoni B型的肿瘤。它还偶尔对波形蛋白呈阳性反应，对S-100和NSE呈弥漫性阳性反应。
结论
该肿瘤是起源于肝门管区的神经鞘瘤。
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