Fernández Colomer B, Rekarte García S, García López J E, Pérez González C, Montes Granda M, Coto Cotallo G D
Servicio de Neonatología, AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
An Pediatr (Barc). 2014 Oct;81(4):251-5. doi: 10.1016/j.anpedi.2013.09.015. Epub 2013 Dec 4.
Valproate-induced hyperammonemic encephalopathy (VHE) is an unusual and serious complication of valproate (VA) treatment. When an early diagnosis is made, it can be reversed with VA withdrawal and early treatment for hyperammonemia. We describe the case of a 20 days old male, who developed a serious VHE after receiving VA for refractory neonatal seizures. The VHE was resolved with VA withdrawal in association with carglumic acid and other measures for hyperammonemia treatment.
丙戊酸盐诱发的高氨血症性脑病（VHE）是丙戊酸盐（VA）治疗中一种罕见且严重的并发症。若能早期诊断，通过停用VA并早期治疗高氨血症，病情可逆转。我们报告一例20日龄男婴，其在接受VA治疗难治性新生儿惊厥后发生严重VHE。通过停用VA并联合应用卡谷氨酸及其他高氨血症治疗措施，VHE得以缓解。
